Negative reciprocal regulation between Sirt1 and Per2 modulates the circadian clock and aging

Negative reciprocal regulation between Sirt1 and Per2 modulates the circadian clock and aging

Sirtuin 1 (SIRT1) is involved in both aging and circadian-clock regulation, yet the link between the two processes in relation to SIRT1 function is not clear. Using Sirt1-deficient mice, we found that Sirt1 and Period 2 (Per2) constitute a reciprocal negative regulation loop that plays important rol...

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Bibliographic Details
Main Authors: Wang, Rui-Hong, Zhao, Tingrui, Cui, Kairong, Hu, Gangqing, Chen, Qiang, Chen, Weiping, Wang, Xin-Wei, Soto-Gutierrez, Alejandro, Zhao, Keji, Deng, Chu-Xia
Format: Online
Language:English
Published: Nature Publishing Group 2016
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4922021/

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4922021/

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