Crosstalk between cellular compartments protects against proteotoxicity and extends lifespan

Crosstalk between cellular compartments protects against proteotoxicity and extends lifespan

In cells living under optimal conditions, protein folding defects are usually prevented by the action of chaperones. Here, we investigate the cell-wide consequences of loss of chaperone function in cytosol, mitochondria or the endoplasmic reticulum (ER) in budding yeast. We find that the decline in...

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Bibliographic Details
Main Authors: Perić, Matea, Dib, Peter Bou, Dennerlein, Sven, Musa, Marina, Rudan, Marina, Lovrić, Anita, Nikolić, Andrea, Šarić, Ana, Sobočanec, Sandra, Mačak, Željka, Raimundo, Nuno, Kriško, Anita
Format: Online
Language:English
Published: Nature Publishing Group 2016
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4921836/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4921836/

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