Branched-chain amino acid restriction in Zucker-fatty rats improves muscle insulin sensitivity by enhancing efficiency of fatty acid oxidation and acyl-glycine export

Branched-chain amino acid restriction in Zucker-fatty rats improves muscle insulin sensitivity by enhancing efficiency of fatty acid oxidation and acyl-glycine export

•Feeding a BCAA restricted diet improves skeletal muscle insulin sensitivity in Zucker fatty rats.•BCKDH activity is decreased in liver and increased in skeletal muscle in Zucker fatty versus lean rats.•High BCAA levels drive the obesity-associated decline in circulating and muscle glycine levels.•B...

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Bibliographic Details
Main Authors: White, Phillip J., Lapworth, Amanda L., An, Jie, Wang, Liping, McGarrah, Robert W., Stevens, Robert D., Ilkayeva, Olga, George, Tabitha, Muehlbauer, Michael J., Bain, James R., Trimmer, Jeff K., Brosnan, M. Julia, Rolph, Timothy P., Newgard, Christopher B.
Format: Online
Language:English
Published: Elsevier 2016
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4921791/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4921791/

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