A novel Drosophila model of TDP-43 proteinopathies: N-terminal sequences combined with the Q/N domain induce protein functional loss and locomotion defects

A novel Drosophila model of TDP-43 proteinopathies: N-terminal sequences combined with the Q/N domain induce protein functional loss and locomotion defects

Transactive response DNA-binding protein 43 kDa (TDP-43, also known as TBPH in Drosophila melanogaster and TARDBP in mammals) is the main protein component of the pathological inclusions observed in neurons of patients affected by different neurodegenerative disorders, including amyotrophic lateral...

Full description

Bibliographic Details
Main Authors: Langellotti, Simona, Romano, Valentina, Romano, Giulia, Klima, Raffaella, Feiguin, Fabian, Cragnaz, Lucia, Romano, Maurizio, Baralle, Francisco E.
Format: Online
Language:English
Published: The Company of Biologists Ltd 2016
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4920146/

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4920146/

Similar Items