Melittin inhibits tumor angiogenesis modulated by endothelial progenitor cells associated with the SDF-1α/CXCR4 signaling pathway in a UMR-106 osteosarcoma xenograft mouse model

Melittin inhibits tumor angiogenesis modulated by endothelial progenitor cells associated with the SDF-1α/CXCR4 signaling pathway in a UMR-106 osteosarcoma xenograft mouse model

Endothelial progenitor cells (EPCs) are important in tumor angiogenesis. Stromal cell-derived factor-1α (SDF-1α) and its receptor C-X-C chemokine receptor type 4 (CXCR4) are key in stem cell homing. Melittin, a component of bee venom, exerts antitumor activity, however, the underlying mechanisms rem...

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Bibliographic Details
Main Authors: QIN, GANG, CHEN, YONGQIANG, LI, HAIDONG, XU, SUYANG, LI, YUMEI, SUN, JIAN, RAO, WU, CHEN, CHAOWEI, DU, MINDONG, HE, KAIYI, YE, YONG
Format: Online
Language:English
Published: D.A. Spandidos 2016
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4918564/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4918564/

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