Phylodynamics of H1N1/2009 influenza reveals the transition from host adaptation to immune-driven selection
Influenza A H1N1/2009 virus that emerged from swine rapidly replaced the previous seasonal H1N1 virus. Although the early emergence and diversification of H1N1/2009 is well characterized, the ongoing evolutionary and global transmission dynamics of the virus remain poorly investigated. To address th...
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Nature Publishing Group
2015
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4918339/ |
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pubmed-49183392016-07-07 Phylodynamics of H1N1/2009 influenza reveals the transition from host adaptation to immune-driven selection Su, Yvonne C. F. Bahl, Justin Joseph, Udayan Butt, Ka Man Peck, Heidi A. Koay, Evelyn S. C. Oon, Lynette L. E. Barr, Ian G. Vijaykrishna, Dhanasekaran Smith, Gavin J. D. Article Influenza A H1N1/2009 virus that emerged from swine rapidly replaced the previous seasonal H1N1 virus. Although the early emergence and diversification of H1N1/2009 is well characterized, the ongoing evolutionary and global transmission dynamics of the virus remain poorly investigated. To address this we analyse >3,000 H1N1/2009 genomes, including 214 full genomes generated from our surveillance in Singapore, in conjunction with antigenic data. Here we show that natural selection acting on H1N1/2009 directly after introduction into humans was driven by adaptation to the new host. Since then, selection has been driven by immunological escape, with these changes corresponding to restricted antigenic diversity in the virus population. We also show that H1N1/2009 viruses have been subject to regular seasonal bottlenecks and a global reduction in antigenic and genetic diversity in 2014. Nature Publishing Group 2015-08-06 /pmc/articles/PMC4918339/ /pubmed/26245473 http://dx.doi.org/10.1038/ncomms8952 Text en Copyright © 2015, Nature Publishing Group, a division of Macmillan Publishers Limited. All Rights Reserved. http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ |
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Open Access Journal |
| institution_category |
Foreign Institution |
| institution |
US National Center for Biotechnology Information |
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NCBI PubMed |
| collection |
Online Access |
| language |
English |
| format |
Online |
| author |
Su, Yvonne C. F. Bahl, Justin Joseph, Udayan Butt, Ka Man Peck, Heidi A. Koay, Evelyn S. C. Oon, Lynette L. E. Barr, Ian G. Vijaykrishna, Dhanasekaran Smith, Gavin J. D. |
| spellingShingle |
Su, Yvonne C. F. Bahl, Justin Joseph, Udayan Butt, Ka Man Peck, Heidi A. Koay, Evelyn S. C. Oon, Lynette L. E. Barr, Ian G. Vijaykrishna, Dhanasekaran Smith, Gavin J. D. Phylodynamics of H1N1/2009 influenza reveals the transition from host adaptation to immune-driven selection |
| author_facet |
Su, Yvonne C. F. Bahl, Justin Joseph, Udayan Butt, Ka Man Peck, Heidi A. Koay, Evelyn S. C. Oon, Lynette L. E. Barr, Ian G. Vijaykrishna, Dhanasekaran Smith, Gavin J. D. |
| author_sort |
Su, Yvonne C. F. |
| title |
Phylodynamics of H1N1/2009 influenza reveals the transition from host adaptation to immune-driven selection |
| title_short |
Phylodynamics of H1N1/2009 influenza reveals the transition from host adaptation to immune-driven selection |
| title_full |
Phylodynamics of H1N1/2009 influenza reveals the transition from host adaptation to immune-driven selection |
| title_fullStr |
Phylodynamics of H1N1/2009 influenza reveals the transition from host adaptation to immune-driven selection |
| title_full_unstemmed |
Phylodynamics of H1N1/2009 influenza reveals the transition from host adaptation to immune-driven selection |
| title_sort |
phylodynamics of h1n1/2009 influenza reveals the transition from host adaptation to immune-driven selection |
| description |
Influenza A H1N1/2009 virus that emerged from swine rapidly replaced the previous seasonal H1N1 virus. Although the early emergence and diversification of H1N1/2009 is well characterized, the ongoing evolutionary and global transmission dynamics of the virus remain poorly investigated. To address this we analyse >3,000 H1N1/2009 genomes, including 214 full genomes generated from our surveillance in Singapore, in conjunction with antigenic data. Here we show that natural selection acting on H1N1/2009 directly after introduction into humans was driven by adaptation to the new host. Since then, selection has been driven by immunological escape, with these changes corresponding to restricted antigenic diversity in the virus population. We also show that H1N1/2009 viruses have been subject to regular seasonal bottlenecks and a global reduction in antigenic and genetic diversity in 2014. |
| publisher |
Nature Publishing Group |
| publishDate |
2015 |
| url |
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4918339/ |
| _version_ |
1613598740844642304 |