Impaired dynamic cerebrovascular response to hypercapnia predicts development of white matter hyperintensities

Impaired dynamic cerebrovascular response to hypercapnia predicts development of white matter hyperintensities

•Vascular responses are slower in normal white matter that progresses to disease.•Steady-state cerebrovascular reactivity is reduced in normal white matter that progresses to disease.•Cerebrovascular dysregulation occurs before development of leukoaraiosis.

Bibliographic Details
Main Authors: Sam, Kevin, Conklin, John, Holmes, Kenneth R., Sobczyk, Olivia, Poublanc, Julien, Crawley, Adrian P., Mandell, Daniel M., Venkatraghavan, Lakshmikumar, Duffin, James, Fisher, Joseph A., Black, Sandra E., Mikulis, David J.
Format: Online
Language:English
Published: Elsevier 2016
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4917393/

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4917393/

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