Prion Protein Deficiency Causes Diverse Proteome Shifts in Cell Models That Escape Detection in Brain Tissue

A popular method for studying the function of a given protein is to generate and characterize a suitable model deficient for its expression. For the prion protein (PrP), best known for its role in several invariably fatal neurodegenerative diseases, a natural choice, therefore, would be to undertake...

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Bibliographic Details
Main Authors: Mehrabian, Mohadeseh, Brethour, Dylan, Williams, Declan, Wang, Hansen, Arnould, Hélène, Schneider, Benoit, Schmitt-Ulms, Gerold
Format: Online
Language:English
Published: Public Library of Science 2016
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4915660/