Prognostic value of decreased expression of RBM4 in human gastric cancer
RNA-binding motif 4 (RBM4) is a multifunctional protein that participates in regulating alternative splicing and mRNA translation. Its reduced expression has been associated with poor overall survival in lung cancer, breast cancer and ovarian cancer. We assessed RBM4 protein expression levels with i...
| Main Authors: | , , , , , , , , , , , , , , , |
|---|---|
| Format: | Online |
| Language: | English |
| Published: |
Nature Publishing Group
2016
|
| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4915006/ |
| id |
pubmed-4915006 |
|---|---|
| recordtype |
oai_dc |
| spelling |
pubmed-49150062016-06-27 Prognostic value of decreased expression of RBM4 in human gastric cancer Yong, Hongmei Zhu, Huijun Zhang, Shu Zhao, Wei Wang, Wei Chen, Chen Ding, Guipeng Zhu, Lun Zhu, Ziyuan Liu, Huaidong Zhang, Yongjie Wen, Jinbo Kang, Xing Zhu, Jin Feng, Zhenqing Liu, Baorui Article RNA-binding motif 4 (RBM4) is a multifunctional protein that participates in regulating alternative splicing and mRNA translation. Its reduced expression has been associated with poor overall survival in lung cancer, breast cancer and ovarian cancer. We assessed RBM4 protein expression levels with immunohistochemistry in tissue microarrays containing malignant gastric cancer tissues and benign tissues from 813 patients. We also examined the expression levels of RBM4 mRNA in twenty-five paired gastric cancer samples and adjacent noncancerous tissues. Both RBM4 protein and mRNA expression levels were significantly lower in gastric cancer tissues compared with the adjacent noncancerous tissues. There was a significant association between reduced RBM4 protein expression and differentiation (P < 0.001), lymph node metastasis (P = 0.026), TNM state (P = 0.014) and distant metastasis (P = 0.036). Patients with reduced RBM4 expression (P < 0.001, CI = 0.315–0.710) and TNM stage III and IV (P < 0.001, CI = 4.757–11.166) had a poor overall survival. These findings suggest that RBM4 is a new biomarker in gastric cancer, as the reduced expression of this protein is correlated with poor differentiation, lymph node status and distant metastasis. Further, lower RBM4 expression is an independent prognostic marker for gastric cancer. Nature Publishing Group 2016-06-21 /pmc/articles/PMC4915006/ /pubmed/27324405 http://dx.doi.org/10.1038/srep28222 Text en Copyright © 2016, Macmillan Publishers Limited http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ |
| repository_type |
Open Access Journal |
| institution_category |
Foreign Institution |
| institution |
US National Center for Biotechnology Information |
| building |
NCBI PubMed |
| collection |
Online Access |
| language |
English |
| format |
Online |
| author |
Yong, Hongmei Zhu, Huijun Zhang, Shu Zhao, Wei Wang, Wei Chen, Chen Ding, Guipeng Zhu, Lun Zhu, Ziyuan Liu, Huaidong Zhang, Yongjie Wen, Jinbo Kang, Xing Zhu, Jin Feng, Zhenqing Liu, Baorui |
| spellingShingle |
Yong, Hongmei Zhu, Huijun Zhang, Shu Zhao, Wei Wang, Wei Chen, Chen Ding, Guipeng Zhu, Lun Zhu, Ziyuan Liu, Huaidong Zhang, Yongjie Wen, Jinbo Kang, Xing Zhu, Jin Feng, Zhenqing Liu, Baorui Prognostic value of decreased expression of RBM4 in human gastric cancer |
| author_facet |
Yong, Hongmei Zhu, Huijun Zhang, Shu Zhao, Wei Wang, Wei Chen, Chen Ding, Guipeng Zhu, Lun Zhu, Ziyuan Liu, Huaidong Zhang, Yongjie Wen, Jinbo Kang, Xing Zhu, Jin Feng, Zhenqing Liu, Baorui |
| author_sort |
Yong, Hongmei |
| title |
Prognostic value of decreased expression of RBM4 in human gastric cancer |
| title_short |
Prognostic value of decreased expression of RBM4 in human gastric cancer |
| title_full |
Prognostic value of decreased expression of RBM4 in human gastric cancer |
| title_fullStr |
Prognostic value of decreased expression of RBM4 in human gastric cancer |
| title_full_unstemmed |
Prognostic value of decreased expression of RBM4 in human gastric cancer |
| title_sort |
prognostic value of decreased expression of rbm4 in human gastric cancer |
| description |
RNA-binding motif 4 (RBM4) is a multifunctional protein that participates in regulating alternative splicing and mRNA translation. Its reduced expression has been associated with poor overall survival in lung cancer, breast cancer and ovarian cancer. We assessed RBM4 protein expression levels with immunohistochemistry in tissue microarrays containing malignant gastric cancer tissues and benign tissues from 813 patients. We also examined the expression levels of RBM4 mRNA in twenty-five paired gastric cancer samples and adjacent noncancerous tissues. Both RBM4 protein and mRNA expression levels were significantly lower in gastric cancer tissues compared with the adjacent noncancerous tissues. There was a significant association between reduced RBM4 protein expression and differentiation (P < 0.001), lymph node metastasis (P = 0.026), TNM state (P = 0.014) and distant metastasis (P = 0.036). Patients with reduced RBM4 expression (P < 0.001, CI = 0.315–0.710) and TNM stage III and IV (P < 0.001, CI = 4.757–11.166) had a poor overall survival. These findings suggest that RBM4 is a new biomarker in gastric cancer, as the reduced expression of this protein is correlated with poor differentiation, lymph node status and distant metastasis. Further, lower RBM4 expression is an independent prognostic marker for gastric cancer. |
| publisher |
Nature Publishing Group |
| publishDate |
2016 |
| url |
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4915006/ |
| _version_ |
1613597420929679360 |