Maternal exposure to air pollutant PM2.5 and PM10 during pregnancy and risk of congenital heart defects

Maternal exposure to ambient air pollution has increasingly been linked to congenital heart defects (CHDs). The objective of this study was to evaluate whether high levels of maternal exposure to PM2.5 and PM10 are related to increased risk of CHDs in Wuhan, China. We conducted a cohort study with a...

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Main Authors:	Zhang, Bin, Liang, Shengwen, Zhao, Jinzhu, Qian, Zhengmin, Bassig, Bryan A, Yang, Rong, Zhang, Yiming, Hu, Ke, Xu, Shunqing, Zheng, Tongzhang, Yang, Shaoping
Format:	Online
Language:	English
Published:	Nature Publishing Group 2016
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4913168/

id	pubmed-4913168
recordtype	oai_dc
spelling	pubmed-49131682016-06-29 Maternal exposure to air pollutant PM2.5 and PM10 during pregnancy and risk of congenital heart defects Zhang, Bin Liang, Shengwen Zhao, Jinzhu Qian, Zhengmin Bassig, Bryan A Yang, Rong Zhang, Yiming Hu, Ke Xu, Shunqing Zheng, Tongzhang Yang, Shaoping Original Article Maternal exposure to ambient air pollution has increasingly been linked to congenital heart defects (CHDs). The objective of this study was to evaluate whether high levels of maternal exposure to PM2.5 and PM10 are related to increased risk of CHDs in Wuhan, China. We conducted a cohort study with a total of 105,988 live-born infants, stillbirths, and fetal deaths. The study included mothers living in the urban district of Wuhan during pregnancy over the 2-year period from 10 June 2011 to 9 June 2013. For each study participant, we assigned 1-month and 1-week averages of PM10 and PM2.5 exposure based on measurements obtained from the nearest exposure monitor to the living residence of mothers during their early pregnancy period. Logistic regression analyses were conducted to calculate the adjusted odds ratios (aORs) and 95% confidence intervals (CI) for the association between exposure to these ambient air pollutants during early pregnancy and CHDs. We observed an increased risk of CHDs, particularly ventricular septal defect (VSD), with increasing PM2.5 exposure. Using 1-week averages, we also observed significant monotonically increasing associations between PM2.5 exposure during weeks 7–10 of pregnancy and risk of VSD, with aORs ranging from 1.11 to 1.17 (95% CI: 1.02–1.20, 1.03–1.22, 1.05–1.24, and 1.08–1.26 separately) per a 10 μg/m3 change in PM2.5 concentration. Our study contributes to the small body of knowledge regarding the association between in utero exposure to air pollution and CHDs, but confirmation of these associations will be needed in future studies. Nature Publishing Group 2016-06 2016-02-17 /pmc/articles/PMC4913168/ /pubmed/26883477 http://dx.doi.org/10.1038/jes.2016.1 Text en Copyright © 2016 Nature America, Inc. http://creativecommons.org/licenses/by-nc-sa/4.0/ This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-sa/4.0/
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Zhang, Bin Liang, Shengwen Zhao, Jinzhu Qian, Zhengmin Bassig, Bryan A Yang, Rong Zhang, Yiming Hu, Ke Xu, Shunqing Zheng, Tongzhang Yang, Shaoping
spellingShingle	Zhang, Bin Liang, Shengwen Zhao, Jinzhu Qian, Zhengmin Bassig, Bryan A Yang, Rong Zhang, Yiming Hu, Ke Xu, Shunqing Zheng, Tongzhang Yang, Shaoping Maternal exposure to air pollutant PM2.5 and PM10 during pregnancy and risk of congenital heart defects
author_facet	Zhang, Bin Liang, Shengwen Zhao, Jinzhu Qian, Zhengmin Bassig, Bryan A Yang, Rong Zhang, Yiming Hu, Ke Xu, Shunqing Zheng, Tongzhang Yang, Shaoping
author_sort	Zhang, Bin
title	Maternal exposure to air pollutant PM2.5 and PM10 during pregnancy and risk of congenital heart defects
title_short	Maternal exposure to air pollutant PM2.5 and PM10 during pregnancy and risk of congenital heart defects
title_full	Maternal exposure to air pollutant PM2.5 and PM10 during pregnancy and risk of congenital heart defects
title_fullStr	Maternal exposure to air pollutant PM2.5 and PM10 during pregnancy and risk of congenital heart defects
title_full_unstemmed	Maternal exposure to air pollutant PM2.5 and PM10 during pregnancy and risk of congenital heart defects
title_sort	maternal exposure to air pollutant pm2.5 and pm10 during pregnancy and risk of congenital heart defects
description	Maternal exposure to ambient air pollution has increasingly been linked to congenital heart defects (CHDs). The objective of this study was to evaluate whether high levels of maternal exposure to PM2.5 and PM10 are related to increased risk of CHDs in Wuhan, China. We conducted a cohort study with a total of 105,988 live-born infants, stillbirths, and fetal deaths. The study included mothers living in the urban district of Wuhan during pregnancy over the 2-year period from 10 June 2011 to 9 June 2013. For each study participant, we assigned 1-month and 1-week averages of PM10 and PM2.5 exposure based on measurements obtained from the nearest exposure monitor to the living residence of mothers during their early pregnancy period. Logistic regression analyses were conducted to calculate the adjusted odds ratios (aORs) and 95% confidence intervals (CI) for the association between exposure to these ambient air pollutants during early pregnancy and CHDs. We observed an increased risk of CHDs, particularly ventricular septal defect (VSD), with increasing PM2.5 exposure. Using 1-week averages, we also observed significant monotonically increasing associations between PM2.5 exposure during weeks 7–10 of pregnancy and risk of VSD, with aORs ranging from 1.11 to 1.17 (95% CI: 1.02–1.20, 1.03–1.22, 1.05–1.24, and 1.08–1.26 separately) per a 10 μg/m3 change in PM2.5 concentration. Our study contributes to the small body of knowledge regarding the association between in utero exposure to air pollution and CHDs, but confirmation of these associations will be needed in future studies.
publisher	Nature Publishing Group
publishDate	2016
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4913168/
_version_	1613596739059580928

Maternal exposure to air pollutant PM2.5 and PM10 during pregnancy and risk of congenital heart defects

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