Myeloid thrombomodulin lectin-like domain inhibits osteoclastogenesis and inflammatory bone loss

Osteoclastogenesis is an essential process during bone metabolism which can also be promoted by inflammatory signals. Thrombomodulin (TM), a transmembrane glycoprotein, exerts anti-inflammatory activities such as neutralization of proinflammatory high-mobility group box 1 (HMGB1) through TM lectin-l...

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Bibliographic Details
Main Authors: Cheng, Tsung-Lin, Lai, Chao-Han, Shieh, Shyh-Jou, Jou, Yin-Bo, Yeh, Jwu-Lai, Yang, Ai-Lun, Wang, Yan-Hsiung, Wang, Chau-Zen, Chen, Chung-Hwan, Shi, Guey-Yueh, Ho, Mei-Ling, Wu, Hua-Lin
Format: Online
Language:English
Published: Nature Publishing Group 2016
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4911607/