Age-Associated Decrease of the Histone Methyltransferase SUV39H1 in HSC Perturbs Heterochromatin and B Lymphoid Differentiation

Age-Associated Decrease of the Histone Methyltransferase SUV39H1 in HSC Perturbs Heterochromatin and B Lymphoid Differentiation

The capacity of hematopoietic stem cells (HSC) to generate B lymphocytes declines with age, contributing to impaired immune function in the elderly. Here we show that the histone methyltransferase SUV39H1 plays an important role in human B lymphoid differentiation and that expression of SUV39H1 decr...

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Bibliographic Details
Main Authors: Djeghloul, Dounia, Kuranda, Klaudia, Kuzniak, Isabelle, Barbieri, Daniela, Naguibneva, Irina, Choisy, Caroline, Bories, Jean-Christophe, Dosquet, Christine, Pla, Marika, Vanneaux, Valérie, Socié, Gérard, Porteu, Françoise, Garrick, David, Goodhardt, Michele
Format: Online
Language:English
Published: Elsevier 2016
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4911502/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4911502/

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