Fatal canine distemper virus infection of giant pandas in China

We report an outbreak of canine distemper virus (CDV) infection among endangered giant pandas (Ailuropoda melanoleuca). Five of six CDV infected giant pandas died. The surviving giant panda was previously vaccinated against CDV. Genomic sequencing of CDV isolated from one of the infected pandas (gia...

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Main Authors:	Feng, Na, Yu, Yicong, Wang, Tiecheng, Wilker, Peter, Wang, Jianzhong, Li, Yuanguo, Sun, Zhe, Gao, Yuwei, Xia, Xianzhu
Format:	Online
Language:	English
Published:	Nature Publishing Group 2016
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4910525/

id	pubmed-4910525
recordtype	oai_dc
spelling	pubmed-49105252016-06-17 Fatal canine distemper virus infection of giant pandas in China Feng, Na Yu, Yicong Wang, Tiecheng Wilker, Peter Wang, Jianzhong Li, Yuanguo Sun, Zhe Gao, Yuwei Xia, Xianzhu Article We report an outbreak of canine distemper virus (CDV) infection among endangered giant pandas (Ailuropoda melanoleuca). Five of six CDV infected giant pandas died. The surviving giant panda was previously vaccinated against CDV. Genomic sequencing of CDV isolated from one of the infected pandas (giant panda/SX/2014) suggests it belongs to the Asia-1 cluster. The hemagglutinin protein of the isolated virus and virus sequenced from lung samples originating from deceased giant pandas all possessed the substitutions V26M, T213A, K281R, S300N, P340Q, and Y549H. The presence of the Y549H substitution is notable as it is found at the signaling lymphocytic activation molecule (SLAM) receptor-binding site and has been implicated in the emergence of highly pathogenic CDV and host switching. These findings demonstrate that giant pandas are susceptible to CDV and suggest that surveillance and vaccination among all captive giant pandas are warranted to support conservation efforts for this endangered species. Nature Publishing Group 2016-06-16 /pmc/articles/PMC4910525/ /pubmed/27310722 http://dx.doi.org/10.1038/srep27518 Text en Copyright © 2016, Macmillan Publishers Limited http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Feng, Na Yu, Yicong Wang, Tiecheng Wilker, Peter Wang, Jianzhong Li, Yuanguo Sun, Zhe Gao, Yuwei Xia, Xianzhu
spellingShingle	Feng, Na Yu, Yicong Wang, Tiecheng Wilker, Peter Wang, Jianzhong Li, Yuanguo Sun, Zhe Gao, Yuwei Xia, Xianzhu Fatal canine distemper virus infection of giant pandas in China
author_facet	Feng, Na Yu, Yicong Wang, Tiecheng Wilker, Peter Wang, Jianzhong Li, Yuanguo Sun, Zhe Gao, Yuwei Xia, Xianzhu
author_sort	Feng, Na
title	Fatal canine distemper virus infection of giant pandas in China
title_short	Fatal canine distemper virus infection of giant pandas in China
title_full	Fatal canine distemper virus infection of giant pandas in China
title_fullStr	Fatal canine distemper virus infection of giant pandas in China
title_full_unstemmed	Fatal canine distemper virus infection of giant pandas in China
title_sort	fatal canine distemper virus infection of giant pandas in china
description	We report an outbreak of canine distemper virus (CDV) infection among endangered giant pandas (Ailuropoda melanoleuca). Five of six CDV infected giant pandas died. The surviving giant panda was previously vaccinated against CDV. Genomic sequencing of CDV isolated from one of the infected pandas (giant panda/SX/2014) suggests it belongs to the Asia-1 cluster. The hemagglutinin protein of the isolated virus and virus sequenced from lung samples originating from deceased giant pandas all possessed the substitutions V26M, T213A, K281R, S300N, P340Q, and Y549H. The presence of the Y549H substitution is notable as it is found at the signaling lymphocytic activation molecule (SLAM) receptor-binding site and has been implicated in the emergence of highly pathogenic CDV and host switching. These findings demonstrate that giant pandas are susceptible to CDV and suggest that surveillance and vaccination among all captive giant pandas are warranted to support conservation efforts for this endangered species.
publisher	Nature Publishing Group
publishDate	2016
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4910525/
_version_	1613595819887296512

Fatal canine distemper virus infection of giant pandas in China

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