Microglia regulate hippocampal neurogenesis during chronic neurodegeneration
•Microglia are proneurogenic in a model of prion disease.•Blocking the expansion of microglia prevents the aberrant differentiation of newborn neurons.•TGFβ dominates the proneurogenic actions of microglia during chronic neurodegeneration.
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Online |
| Language: | English |
| Published: |
Elsevier
2016
|
| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4907582/ |