Oral Challenge with Wild-Type Salmonella Typhi Induces Distinct Changes in B Cell Subsets in Individuals Who Develop Typhoid Disease

Oral Challenge with Wild-Type Salmonella Typhi Induces Distinct Changes in B Cell Subsets in Individuals Who Develop Typhoid Disease

A novel human oral challenge model with wild-type Salmonella Typhi (S. Typhi) was recently established by the Oxford Vaccine Group. In this model, 104 CFU of Salmonella resulted in 65% of participants developing typhoid fever (referred here as typhoid diagnosis -TD-) 6–9 days post-challenge. TD was...

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Bibliographic Details
Main Authors: Toapanta, Franklin R., Bernal, Paula J., Fresnay, Stephanie, Magder, Laurence S., Darton, Thomas C., Jones, Claire, Waddington, Claire S., Blohmke, Christoph J., Angus, Brian, Levine, Myron M., Pollard, Andrew J., Sztein, Marcelo B.
Format: Online
Language:English
Published: Public Library of Science 2016
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4907489/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4907489/

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