Dihydrostreptomycin Directly Binds to, Modulates, and Passes through the MscL Channel Pore

The primary mechanism of action of the antibiotic dihydrostreptomycin is binding to and modifying the function of the bacterial ribosome, thus leading to decreased and aberrant translation of proteins; however, the routes by which it enters the bacterial cell are largely unknown. The mechanosensitiv...

Full description

Bibliographic Details
Main Authors: Wray, Robin, Iscla, Irene, Gao, Ya, Li, Hua, Wang, Junmei, Blount, Paul
Format: Online
Language:English
Published: Public Library of Science 2016
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4900634/