Deletion of nuoG from the Vaccine Candidate Mycobacterium bovis BCG ΔureC::hly Improves Protection against Tuberculosis

Deletion of nuoG from the Vaccine Candidate Mycobacterium bovis BCG ΔureC::hly Improves Protection against Tuberculosis

The current tuberculosis (TB) vaccine, Mycobacterium bovis Bacillus Calmette-Guérin (BCG), provides insufficient protection against pulmonary TB. Previously, we generated a listeriolysin-expressing recombinant BCG strain, which to date has successfully completed phase I and phase IIa clinical trials...

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Bibliographic Details
Main Authors: Gengenbacher, Martin, Nieuwenhuizen, Natalie, Vogelzang, Alexis, Liu, Haipeng, Kaiser, Peggy, Schuerer, Stefanie, Lazar, Doris, Wagner, Ina, Mollenkopf, Hans-Joachim, Kaufmann, Stefan H. E.
Format: Online
Language:English
Published: American Society for Microbiology 2016
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4895111/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4895111/

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