Effective Cytotoxic T Lymphocyte Targeting of Persistent HIV-1 during Antiretroviral Therapy Requires Priming of Naive CD8+ T Cells

Effective Cytotoxic T Lymphocyte Targeting of Persistent HIV-1 during Antiretroviral Therapy Requires Priming of Naive CD8+ T Cells

Curing HIV-1 infection will require elimination of persistent cellular reservoirs that harbor latent virus in the face of combination antiretroviral therapy (cART). Proposed immunotherapeutic strategies to cure HIV-1 infection include enhancing lysis of these infected cells by cytotoxic T lymphocyte...

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Bibliographic Details
Main Authors: Smith, Kellie N., Mailliard, Robbie B., Piazza, Paolo A., Fischer, Will, Korber, Bette T., Fecek, Ronald J., Ratner, Deena, Gupta, Phalguni, Mullins, James I., Rinaldo, Charles R.
Format: Online
Language:English
Published: American Society for Microbiology 2016
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4895106/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4895106/

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