Perlecan/HSPG2 and matrilysin/MMP-7 as indices of tissue invasion: tissue localization and circulating perlecan fragments in a cohort of 288 radical prostatectomy patients

Perlecan/HSPG2 and matrilysin/MMP-7 as indices of tissue invasion: tissue localization and circulating perlecan fragments in a cohort of 288 radical prostatectomy patients

Prostate cancer (PCa) cells use matrix metalloproteinases (MMPs) to degrade tissue during invasion. Perlecan/HSPG2 is degraded at basement membranes, in reactive stroma and in bone marrow during metastasis. We previously showed MMP-7 efficiently degrades perlecan. We now analyzed PCa tissue and seru...

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Bibliographic Details
Main Authors: Grindel, Brian, Li, Quanlin, Arnold, Rebecca, Petros, John, Zayzafoon, Majd, Muldoon, Mark, Stave, James, Chung, Leland W. K., Farach-Carson, Mary C.
Format: Online
Language:English
Published: Impact Journals LLC 2016
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4891130/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4891130/

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