eIF4B is a convergent target and critical effector of oncogenic Pim and PI3K/Akt/mTOR signaling pathways in Abl transformants

eIF4B is a convergent target and critical effector of oncogenic Pim and PI3K/Akt/mTOR signaling pathways in Abl transformants

Activation of eIF4B correlates with Abl-mediated cellular transformation, but the precise mechanisms are largely unknown. Here we show that eIF4B is a convergent substrate of JAK/STAT/Pim and PI3K/Akt/mTOR pathways in Abl transformants. Both pathways phosphorylated eIF4B in Abl-transformed cells, an...

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Bibliographic Details
Main Authors: Chen, Ke, Yang, Jianling, Li, Jianning, Wang, Xuefei, Chen, Yuhai, Huang, Shile, Chen, Ji-Long
Format: Online
Language:English
Published: Impact Journals LLC 2016
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4891105/

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4891105/

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