Hepatic Encephalopathy: From the Pathogenesis to the New Treatments
Hepatic encephalopathy is a frequent and serious complication of liver cirrhosis; the pathophysiology of this complication is not fully understood although great efforts have been made during the last years. There are few prospective studies on the epidemiology of this complication; however, it is k...
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| Format: | Online |
| Language: | English |
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Hindawi Publishing Corporation
2014
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4890879/ |
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pubmed-4890879 |
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pubmed-48908792016-06-22 Hepatic Encephalopathy: From the Pathogenesis to the New Treatments Cordoba, Juan Review Article Hepatic encephalopathy is a frequent and serious complication of liver cirrhosis; the pathophysiology of this complication is not fully understood although great efforts have been made during the last years. There are few prospective studies on the epidemiology of this complication; however, it is known that it confers with high short-term mortality. Hepatic encephalopathy has been classified into different groups depending on the degree of hepatic dysfunction, the presence of portal-systemic shunts, and the number of episodes. Due to the large clinical spectra of overt EH and the complexity of cirrhotic patients, it is very difficult to perform quality clinical trials for assessing the efficacy of the treatments proposed. The physiopathology, clinical manifestation, and the treatment of HE is a challenge because of the multiple factors that converge and coexist in an episode of overt HE. Hindawi Publishing Corporation 2014-06-04 /pmc/articles/PMC4890879/ /pubmed/27335836 http://dx.doi.org/10.1155/2014/236268 Text en Copyright © 2014 Juan Cordoba. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
| repository_type |
Open Access Journal |
| institution_category |
Foreign Institution |
| institution |
US National Center for Biotechnology Information |
| building |
NCBI PubMed |
| collection |
Online Access |
| language |
English |
| format |
Online |
| author |
Cordoba, Juan |
| spellingShingle |
Cordoba, Juan Hepatic Encephalopathy: From the Pathogenesis to the New Treatments |
| author_facet |
Cordoba, Juan |
| author_sort |
Cordoba, Juan |
| title |
Hepatic Encephalopathy: From the Pathogenesis to the New Treatments |
| title_short |
Hepatic Encephalopathy: From the Pathogenesis to the New Treatments |
| title_full |
Hepatic Encephalopathy: From the Pathogenesis to the New Treatments |
| title_fullStr |
Hepatic Encephalopathy: From the Pathogenesis to the New Treatments |
| title_full_unstemmed |
Hepatic Encephalopathy: From the Pathogenesis to the New Treatments |
| title_sort |
hepatic encephalopathy: from the pathogenesis to the new treatments |
| description |
Hepatic encephalopathy is a frequent and serious complication of liver cirrhosis; the pathophysiology of this complication is not fully understood although great efforts have been made during the last years. There are few prospective studies on the epidemiology of this complication; however, it is known that it confers with high short-term mortality. Hepatic encephalopathy has been classified into different groups depending on the degree of hepatic dysfunction, the presence of portal-systemic shunts, and the number of episodes. Due to the large clinical spectra of overt EH and the complexity of cirrhotic patients, it is very difficult to perform quality clinical trials for assessing the efficacy of the treatments proposed. The physiopathology, clinical manifestation, and the treatment of HE is a challenge because of the multiple factors that converge and coexist in an episode of overt HE. |
| publisher |
Hindawi Publishing Corporation |
| publishDate |
2014 |
| url |
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4890879/ |
| _version_ |
1613587959960829952 |