NMNAT2:HSP90 Complex Mediates Proteostasis in Proteinopathies

NMNAT2:HSP90 Complex Mediates Proteostasis in Proteinopathies

Nicotinamide mononucleotide adenylyl transferase 2 (NMNAT2) is neuroprotective in numerous preclinical models of neurodegeneration. Here, we show that brain nmnat2 mRNA levels correlate positively with global cognitive function and negatively with AD pathology. In AD brains, NMNAT2 mRNA and protein...

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Bibliographic Details
Main Authors: Ali, Yousuf O., Allen, Hunter M., Yu, Lei, Li-Kroeger, David, Bakhshizadehmahmoudi, Dena, Hatcher, Asante, McCabe, Cristin, Xu, Jishu, Bjorklund, Nicole, Taglialatela, Giulio, Bennett, David A., De Jager, Philip L., Shulman, Joshua M., Bellen, Hugo J., Lu, Hui-Chen
Format: Online
Language:English
Published: Public Library of Science 2016
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4890852/

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4890852/

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