N-Ethyl-N-Nitrosourea (ENU) Mutagenesis Reveals an Intronic Residue Critical for Caenorhabditis elegans 3′ Splice Site Function in Vivo

N-Ethyl-N-Nitrosourea (ENU) Mutagenesis Reveals an Intronic Residue Critical for Caenorhabditis elegans 3′ Splice Site Function in Vivo

Metazoan introns contain a polypyrimidine tract immediately upstream of the AG dinucleotide that defines the 3′ splice site. In the nematode Caenorhabditis elegans, 3′ splice sites are characterized by a highly conserved UUUUCAG/R octamer motif. While the conservation of pyrimidines in this motif is...

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Bibliographic Details
Main Authors: Itani, Omar A., Flibotte, Stephane, Dumas, Kathleen J., Guo, Chunfang, Blumenthal, Thomas, Hu, Patrick J.
Format: Online
Language:English
Published: Genetics Society of America 2016
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4889670/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4889670/

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