The first crystal structure of human RNase 6 reveals a novel substrate-binding and cleavage site arrangement
We describe the first human RNase 6 crystal structure in complex with sulfate anions. Kinetic analysis, site-directed mutagenesis and molecular dynamics simulations identified novel substrate recognition and cleavage sites.
| Main Authors: | , , , , , , |
|---|---|
| Format: | Online |
| Language: | English |
| Published: |
Portland Press Ltd.
2016
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4888456/ |