Distribution of drug-resistant bacteria and rational use of clinical antimicrobial agents

Open wound may lead to infection in patients. Due to overuse of medication, certain bacteria have become resistant to drugs currently available. The aim of the present study was to provide a guide to ameliorate the appropriate and rational use of clinical antimicrobial agents by analyzing the distri...

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Main Authors:	ZHOU, CHENLIANG, CHEN, XIAOBING, WU, LIWEN, QU, JING
Format:	Online
Language:	English
Published:	D.A. Spandidos 2016
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4888038/

id	pubmed-4888038
recordtype	oai_dc
spelling	pubmed-48880382016-06-16 Distribution of drug-resistant bacteria and rational use of clinical antimicrobial agents ZHOU, CHENLIANG CHEN, XIAOBING WU, LIWEN QU, JING Articles Open wound may lead to infection in patients. Due to overuse of medication, certain bacteria have become resistant to drugs currently available. The aim of the present study was to provide a guide to ameliorate the appropriate and rational use of clinical antimicrobial agents by analyzing the distribution of drug-resistant pathogenic bacteria in patients. Between October 2013 and January 2015, 126 patients were selected at the Department of Orthopedics. Wound secretion samples were collected, and the pathogen bacteria isolated and identified. Identification was performed using an automated identification instrument and the Kirby-Bauer antibiotic method was used to evaluate the bacterial resistance. Of the 126 patients, 118 patients were infected (infection rate, 93.65%). Additionally, 47 strains of gram-positive pathogenic bacteria (39.83%) and 71 strains of pathogenic-gram negative bacteria (60.17%) were identified. The bacteria were most likely to be resistant to penicillin while sensitive to vancomycin and imipenem. Some bacteria were resistant to several antibacterial agents. The results showed that existing risk factors at the Department of Orthopedics were complex and any non-standard procedures were able to cause bacterial infection. There were obvious dissimilarities among infectious bacteria with regard to their sensitivity to various antibacterial agents. Manipulation techniques during the treatment process were performed in a sterile manner and the use of antibacterial agents was required to be strictly in accordance with the results of drug sensitivity tests to provide effective etiologic information and a treatment plan for clinical trials and to reduce the risk of infection by multi-resistant bacteria. D.A. Spandidos 2016-06 2016-04-08 /pmc/articles/PMC4888038/ /pubmed/27313667 http://dx.doi.org/10.3892/etm.2016.3239 Text en Copyright: © Zhou et al. This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License (https://creativecommons.org/licenses/by-nc-nd/4.0/) , which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	ZHOU, CHENLIANG CHEN, XIAOBING WU, LIWEN QU, JING
spellingShingle	ZHOU, CHENLIANG CHEN, XIAOBING WU, LIWEN QU, JING Distribution of drug-resistant bacteria and rational use of clinical antimicrobial agents
author_facet	ZHOU, CHENLIANG CHEN, XIAOBING WU, LIWEN QU, JING
author_sort	ZHOU, CHENLIANG
title	Distribution of drug-resistant bacteria and rational use of clinical antimicrobial agents
title_short	Distribution of drug-resistant bacteria and rational use of clinical antimicrobial agents
title_full	Distribution of drug-resistant bacteria and rational use of clinical antimicrobial agents
title_fullStr	Distribution of drug-resistant bacteria and rational use of clinical antimicrobial agents
title_full_unstemmed	Distribution of drug-resistant bacteria and rational use of clinical antimicrobial agents
title_sort	distribution of drug-resistant bacteria and rational use of clinical antimicrobial agents
description	Open wound may lead to infection in patients. Due to overuse of medication, certain bacteria have become resistant to drugs currently available. The aim of the present study was to provide a guide to ameliorate the appropriate and rational use of clinical antimicrobial agents by analyzing the distribution of drug-resistant pathogenic bacteria in patients. Between October 2013 and January 2015, 126 patients were selected at the Department of Orthopedics. Wound secretion samples were collected, and the pathogen bacteria isolated and identified. Identification was performed using an automated identification instrument and the Kirby-Bauer antibiotic method was used to evaluate the bacterial resistance. Of the 126 patients, 118 patients were infected (infection rate, 93.65%). Additionally, 47 strains of gram-positive pathogenic bacteria (39.83%) and 71 strains of pathogenic-gram negative bacteria (60.17%) were identified. The bacteria were most likely to be resistant to penicillin while sensitive to vancomycin and imipenem. Some bacteria were resistant to several antibacterial agents. The results showed that existing risk factors at the Department of Orthopedics were complex and any non-standard procedures were able to cause bacterial infection. There were obvious dissimilarities among infectious bacteria with regard to their sensitivity to various antibacterial agents. Manipulation techniques during the treatment process were performed in a sterile manner and the use of antibacterial agents was required to be strictly in accordance with the results of drug sensitivity tests to provide effective etiologic information and a treatment plan for clinical trials and to reduce the risk of infection by multi-resistant bacteria.
publisher	D.A. Spandidos
publishDate	2016
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4888038/
_version_	1613586978834481152

Distribution of drug-resistant bacteria and rational use of clinical antimicrobial agents

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