Prognostic significance of a component of the Hippo pathway, TAZ, in human uterine endometrioid adenocarcinoma

Transcriptional coactivator with PDZ-binding motif (TAZ) is a crucial component of the Hippo tumor suppressor pathway, interacting with transcriptional factors to regulate cell proliferation, apoptosis and tumorigenesis. TAZ and its paralog, Yes-associated protein (YAP), are activated at high freque...

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Main Authors:	ZHAN, MAOSHENG, IKEDA, JUN-ICHIRO, WADA, NAOKI, HORI, YUMIKO, NOJIMA, SATOSHI, TAHARA, SHIN-ICHIRO, UEDA, YUTAKA, YOSHINO, KIYOSHI, KIMURA, TADASHI, MORII, EIICHI
Format:	Online
Language:	English
Published:	D.A. Spandidos 2016
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4887927/

id	pubmed-4887927
recordtype	oai_dc
spelling	pubmed-48879272016-06-09 Prognostic significance of a component of the Hippo pathway, TAZ, in human uterine endometrioid adenocarcinoma ZHAN, MAOSHENG IKEDA, JUN-ICHIRO WADA, NAOKI HORI, YUMIKO NOJIMA, SATOSHI TAHARA, SHIN-ICHIRO UEDA, YUTAKA YOSHINO, KIYOSHI KIMURA, TADASHI MORII, EIICHI Articles Transcriptional coactivator with PDZ-binding motif (TAZ) is a crucial component of the Hippo tumor suppressor pathway, interacting with transcriptional factors to regulate cell proliferation, apoptosis and tumorigenesis. TAZ and its paralog, Yes-associated protein (YAP), are activated at high frequencies during the progression towards malignancy in various tumors. Recently, YAP has been identified to modulate oncogenic features in endometrial adenocarcinoma, and it has also been reported that the nuclear expression of YAP is correlated with the poorly-differentiated form of endometrioid adenocarcinoma. In contrast to YAP, no studies have investigated TAZ expression in endometrioid adenocarcinoma. In the present study, TAZ expression was immunohistochemically examined in 55 clinical samples of endometrioid adenocarcinoma, and the clinical implications were evaluated. The results demonstrated that TAZ was located primarily in the cell nuclei, and that high TAZ expression was significantly correlated with high tumor-factor (P=0.024), stage (P=0.041) and histological grade (P=0.001), lymph node metastasis (P=0.046), recurrence (P=0.002) and a poor prognosis (P=0.007). Furthermore, univariate analysis identified that high TAZ expression was a poor prognostic factor for overall and disease-free survival. To the best of our knowledge, the present case is the first to report the clinical implications of TAZ in endometrioid adenocarcinoma of the uterus. TAZ may become a marker of a poor prognosis in endometrioid adenocarcinoma. D.A. Spandidos 2016-06 2016-04-20 /pmc/articles/PMC4887927/ /pubmed/27284362 http://dx.doi.org/10.3892/ol.2016.4483 Text en Copyright: © Zhan et al. This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License (https://creativecommons.org/licenses/by-nc-nd/4.0/) , which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	ZHAN, MAOSHENG IKEDA, JUN-ICHIRO WADA, NAOKI HORI, YUMIKO NOJIMA, SATOSHI TAHARA, SHIN-ICHIRO UEDA, YUTAKA YOSHINO, KIYOSHI KIMURA, TADASHI MORII, EIICHI
spellingShingle	ZHAN, MAOSHENG IKEDA, JUN-ICHIRO WADA, NAOKI HORI, YUMIKO NOJIMA, SATOSHI TAHARA, SHIN-ICHIRO UEDA, YUTAKA YOSHINO, KIYOSHI KIMURA, TADASHI MORII, EIICHI Prognostic significance of a component of the Hippo pathway, TAZ, in human uterine endometrioid adenocarcinoma
author_facet	ZHAN, MAOSHENG IKEDA, JUN-ICHIRO WADA, NAOKI HORI, YUMIKO NOJIMA, SATOSHI TAHARA, SHIN-ICHIRO UEDA, YUTAKA YOSHINO, KIYOSHI KIMURA, TADASHI MORII, EIICHI
author_sort	ZHAN, MAOSHENG
title	Prognostic significance of a component of the Hippo pathway, TAZ, in human uterine endometrioid adenocarcinoma
title_short	Prognostic significance of a component of the Hippo pathway, TAZ, in human uterine endometrioid adenocarcinoma
title_full	Prognostic significance of a component of the Hippo pathway, TAZ, in human uterine endometrioid adenocarcinoma
title_fullStr	Prognostic significance of a component of the Hippo pathway, TAZ, in human uterine endometrioid adenocarcinoma
title_full_unstemmed	Prognostic significance of a component of the Hippo pathway, TAZ, in human uterine endometrioid adenocarcinoma
title_sort	prognostic significance of a component of the hippo pathway, taz, in human uterine endometrioid adenocarcinoma
description	Transcriptional coactivator with PDZ-binding motif (TAZ) is a crucial component of the Hippo tumor suppressor pathway, interacting with transcriptional factors to regulate cell proliferation, apoptosis and tumorigenesis. TAZ and its paralog, Yes-associated protein (YAP), are activated at high frequencies during the progression towards malignancy in various tumors. Recently, YAP has been identified to modulate oncogenic features in endometrial adenocarcinoma, and it has also been reported that the nuclear expression of YAP is correlated with the poorly-differentiated form of endometrioid adenocarcinoma. In contrast to YAP, no studies have investigated TAZ expression in endometrioid adenocarcinoma. In the present study, TAZ expression was immunohistochemically examined in 55 clinical samples of endometrioid adenocarcinoma, and the clinical implications were evaluated. The results demonstrated that TAZ was located primarily in the cell nuclei, and that high TAZ expression was significantly correlated with high tumor-factor (P=0.024), stage (P=0.041) and histological grade (P=0.001), lymph node metastasis (P=0.046), recurrence (P=0.002) and a poor prognosis (P=0.007). Furthermore, univariate analysis identified that high TAZ expression was a poor prognostic factor for overall and disease-free survival. To the best of our knowledge, the present case is the first to report the clinical implications of TAZ in endometrioid adenocarcinoma of the uterus. TAZ may become a marker of a poor prognosis in endometrioid adenocarcinoma.
publisher	D.A. Spandidos
publishDate	2016
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4887927/
_version_	1613586937579307008

Prognostic significance of a component of the Hippo pathway, TAZ, in human uterine endometrioid adenocarcinoma

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