Sundarban Honey Confers Protection against Isoproterenol-Induced Myocardial Infarction in Wistar Rats
The present study was designed to investigate the cardioprotective effects of Sundarban honey (SH) in rats with isoproterenol- (ISO-) induced myocardial infarction. Adult male Wistar Albino rats were pretreated with Sundarban honey (5 g/kg) daily for a period of 6 weeks. After the treatment period,...
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| Format: | Online |
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Hindawi Publishing Corporation
2016
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4886051/ |
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pubmed-48860512016-06-12 Sundarban Honey Confers Protection against Isoproterenol-Induced Myocardial Infarction in Wistar Rats Afroz, Rizwana Tanvir, E. M. Karim, Nurul Hossain, Md. Sabir Alam, Nadia Gan, Siew Hua Khalil, Md. Ibrahim Research Article The present study was designed to investigate the cardioprotective effects of Sundarban honey (SH) in rats with isoproterenol- (ISO-) induced myocardial infarction. Adult male Wistar Albino rats were pretreated with Sundarban honey (5 g/kg) daily for a period of 6 weeks. After the treatment period, ISO (85 mg/kg) was subcutaneously injected into the rats at 24 h intervals for 2 days. ISO-induced myocardial damage was indicated by increased serum cardiac specific troponin I levels and cardiac marker enzyme activities including creatine kinase-MB, lactate dehydrogenase, aspartate transaminase, and alanine transaminase. Significant increases in serum total cholesterol, triglycerides, and low-density lipoprotein-cholesterol levels were also observed, along with a reduction in the serum high-density lipoprotein-cholesterol level. In addition to these diagnostic markers, the levels of lipid peroxide products were significantly increased. The activities of antioxidant enzymes such as superoxide dismutase, glutathione peroxidase, and glutathione reductase were significantly decreased in the hearts after ISO-induced myocardial infarction. However, pretreatment of ischemic rats with Sundarban honey brought the biochemical parameters to near normalcy, indicating the protective effect of Sundarban honey against ISO-induced ischemia in rats. Histopathological findings of the heart tissues further confirmed the biochemical findings, indicating that Sundarban honey confers protection against ISO-induced oxidative stress in the myocardium. Hindawi Publishing Corporation 2016 2016-05-17 /pmc/articles/PMC4886051/ /pubmed/27294126 http://dx.doi.org/10.1155/2016/6437641 Text en Copyright © 2016 Rizwana Afroz et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
| repository_type |
Open Access Journal |
| institution_category |
Foreign Institution |
| institution |
US National Center for Biotechnology Information |
| building |
NCBI PubMed |
| collection |
Online Access |
| language |
English |
| format |
Online |
| author |
Afroz, Rizwana Tanvir, E. M. Karim, Nurul Hossain, Md. Sabir Alam, Nadia Gan, Siew Hua Khalil, Md. Ibrahim |
| spellingShingle |
Afroz, Rizwana Tanvir, E. M. Karim, Nurul Hossain, Md. Sabir Alam, Nadia Gan, Siew Hua Khalil, Md. Ibrahim Sundarban Honey Confers Protection against Isoproterenol-Induced Myocardial Infarction in Wistar Rats |
| author_facet |
Afroz, Rizwana Tanvir, E. M. Karim, Nurul Hossain, Md. Sabir Alam, Nadia Gan, Siew Hua Khalil, Md. Ibrahim |
| author_sort |
Afroz, Rizwana |
| title |
Sundarban Honey Confers Protection against Isoproterenol-Induced Myocardial Infarction in Wistar Rats |
| title_short |
Sundarban Honey Confers Protection against Isoproterenol-Induced Myocardial Infarction in Wistar Rats |
| title_full |
Sundarban Honey Confers Protection against Isoproterenol-Induced Myocardial Infarction in Wistar Rats |
| title_fullStr |
Sundarban Honey Confers Protection against Isoproterenol-Induced Myocardial Infarction in Wistar Rats |
| title_full_unstemmed |
Sundarban Honey Confers Protection against Isoproterenol-Induced Myocardial Infarction in Wistar Rats |
| title_sort |
sundarban honey confers protection against isoproterenol-induced myocardial infarction in wistar rats |
| description |
The present study was designed to investigate the cardioprotective effects of Sundarban honey (SH) in rats with isoproterenol- (ISO-) induced myocardial infarction. Adult male Wistar Albino rats were pretreated with Sundarban honey (5 g/kg) daily for a period of 6 weeks. After the treatment period, ISO (85 mg/kg) was subcutaneously injected into the rats at 24 h intervals for 2 days. ISO-induced myocardial damage was indicated by increased serum cardiac specific troponin I levels and cardiac marker enzyme activities including creatine kinase-MB, lactate dehydrogenase, aspartate transaminase, and alanine transaminase. Significant increases in serum total cholesterol, triglycerides, and low-density lipoprotein-cholesterol levels were also observed, along with a reduction in the serum high-density lipoprotein-cholesterol level. In addition to these diagnostic markers, the levels of lipid peroxide products were significantly increased. The activities of antioxidant enzymes such as superoxide dismutase, glutathione peroxidase, and glutathione reductase were significantly decreased in the hearts after ISO-induced myocardial infarction. However, pretreatment of ischemic rats with Sundarban honey brought the biochemical parameters to near normalcy, indicating the protective effect of Sundarban honey against ISO-induced ischemia in rats. Histopathological findings of the heart tissues further confirmed the biochemical findings, indicating that Sundarban honey confers protection against ISO-induced oxidative stress in the myocardium. |
| publisher |
Hindawi Publishing Corporation |
| publishDate |
2016 |
| url |
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4886051/ |
| _version_ |
1613586311429488640 |