Sézary Syndrome and Atopic Dermatitis: Comparison of Immunological Aspects and Targets

Sézary Syndrome and Atopic Dermatitis: Comparison of Immunological Aspects and Targets

Sézary syndrome (SS), an aggressive form of erythrodermic pruritic cutaneous T cell lymphoma (CTCL), from an immunological perspective characterized by increased Th2 cytokine levels, elevated serum IgE and impaired cellular immunity. Not only the clinical appearance but also the hallmark immunologic...

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Main Authors: Saulite, Ieva, Hoetzenecker, Wolfram, Weidinger, Stephan, Cozzio, Antonio, Guenova, Emmanuella, Wehkamp, Ulrike
Format: Online
Language:English
Published: Hindawi Publishing Corporation 2016
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4886049/
id pubmed-4886049
recordtype oai_dc
spelling pubmed-48860492016-06-12 Sézary Syndrome and Atopic Dermatitis: Comparison of Immunological Aspects and Targets Saulite, Ieva Hoetzenecker, Wolfram Weidinger, Stephan Cozzio, Antonio Guenova, Emmanuella Wehkamp, Ulrike Review Article Sézary syndrome (SS), an aggressive form of erythrodermic pruritic cutaneous T cell lymphoma (CTCL), from an immunological perspective characterized by increased Th2 cytokine levels, elevated serum IgE and impaired cellular immunity. Not only the clinical appearance but also the hallmark immunological characteristics of SS often share striking similarities with acute flares of atopic dermatitis (AD), a common benign chronic inflammatory skin disease. Given the overlap of several immunological features, the application of similar or even identical therapeutic approaches in certain stages of both diseases may come into consideration. The aim of this review is to compare currently accepted immunological aspects and possible therapeutic targets in AD and SS. Hindawi Publishing Corporation 2016 2016-05-17 /pmc/articles/PMC4886049/ /pubmed/27294147 http://dx.doi.org/10.1155/2016/9717530 Text en Copyright © 2016 Ieva Saulite et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
repository_type Open Access Journal
institution_category Foreign Institution
institution US National Center for Biotechnology Information
building NCBI PubMed
collection Online Access
language English
format Online
author Saulite, Ieva
Hoetzenecker, Wolfram
Weidinger, Stephan
Cozzio, Antonio
Guenova, Emmanuella
Wehkamp, Ulrike
spellingShingle Saulite, Ieva
Hoetzenecker, Wolfram
Weidinger, Stephan
Cozzio, Antonio
Guenova, Emmanuella
Wehkamp, Ulrike
Sézary Syndrome and Atopic Dermatitis: Comparison of Immunological Aspects and Targets
author_facet Saulite, Ieva
Hoetzenecker, Wolfram
Weidinger, Stephan
Cozzio, Antonio
Guenova, Emmanuella
Wehkamp, Ulrike
author_sort Saulite, Ieva
title Sézary Syndrome and Atopic Dermatitis: Comparison of Immunological Aspects and Targets
title_short Sézary Syndrome and Atopic Dermatitis: Comparison of Immunological Aspects and Targets
title_full Sézary Syndrome and Atopic Dermatitis: Comparison of Immunological Aspects and Targets
title_fullStr Sézary Syndrome and Atopic Dermatitis: Comparison of Immunological Aspects and Targets
title_full_unstemmed Sézary Syndrome and Atopic Dermatitis: Comparison of Immunological Aspects and Targets
title_sort sézary syndrome and atopic dermatitis: comparison of immunological aspects and targets
description Sézary syndrome (SS), an aggressive form of erythrodermic pruritic cutaneous T cell lymphoma (CTCL), from an immunological perspective characterized by increased Th2 cytokine levels, elevated serum IgE and impaired cellular immunity. Not only the clinical appearance but also the hallmark immunological characteristics of SS often share striking similarities with acute flares of atopic dermatitis (AD), a common benign chronic inflammatory skin disease. Given the overlap of several immunological features, the application of similar or even identical therapeutic approaches in certain stages of both diseases may come into consideration. The aim of this review is to compare currently accepted immunological aspects and possible therapeutic targets in AD and SS.
publisher Hindawi Publishing Corporation
publishDate 2016
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4886049/
_version_ 1613586310233063424

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