Isolated Loss of PMS2 Immunohistochemical Expression is Frequently Caused by Heterogenous MLH1 Promoter Hypermethylation in Lynch Syndrome Screening for Endometrial Cancer Patients

Isolated Loss of PMS2 Immunohistochemical Expression is Frequently Caused by Heterogenous MLH1 Promoter Hypermethylation in Lynch Syndrome Screening for Endometrial Cancer Patients

Lynch syndrome (LS) is an autosomal-dominant inherited disorder mainly caused by a germline mutation in the DNA mismatch repair (MMR) genes (MLH1, MSH2, MSH6, and PMS2) and is associated with increased risk for various cancers, particularly colorectal cancer and endometrial cancer (EC). Women with L...

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Bibliographic Details
Main Authors: Kato, Aya, Sato, Naoki, Sugawara, Tae, Takahashi, Kazue, Kito, Masahiko, Makino, Kenichi, Sato, Toshiharu, Shimizu, Dai, Shirasawa, Hiromistu, Miura, Hiroshi, Sato, Wataru, Kumazawa, Yukiyo, Sato, Akira, Kumagai, Jin, Terada, Yukihiro
Format: Online
Language:English
Published: Wolters Kluwer Health, Inc 2016
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4885527/

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4885527/

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