Using Cryo-EM to Map Small Ligands on Dynamic Metabolic Enzymes: Studies with Glutamate Dehydrogenase

Using Cryo-EM to Map Small Ligands on Dynamic Metabolic Enzymes: Studies with Glutamate Dehydrogenase

Cryo-electron microscopy (cryo-EM) methods are now being used to determine structures at near-atomic resolution and have great promise in molecular pharmacology, especially in the context of mapping the binding of small-molecule ligands to protein complexes that display conformational flexibility. W...

Full description

Bibliographic Details
Main Authors: Borgnia, Mario J., Banerjee, Soojay, Merk, Alan, Matthies, Doreen, Bartesaghi, Alberto, Rao, Prashant, Pierson, Jason, Earl, Lesley A., Falconieri, Veronica, Subramaniam, Sriram, Milne, Jacqueline L. S.
Format: Online
Language:English
Published: The American Society for Pharmacology and Experimental Therapeutics 2016
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4885502/

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4885502/

Similar Items