Prototype and Chimera-Type Galectins in Placentas with Spontaneous and Recurrent Miscarriages

Galectins are galactose binding proteins and, in addition, factors for a wide range of pathologies in pregnancy. We have analyzed the expression of prototype (gal-1, -2, -7, -10) and chimera-type (gal-3) galectins in the placenta in cases of spontaneous abortions (SPA) and recurrent abortions (RA) i...

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Main Authors:	Unverdorben, Laura, Haufe, Thomas, Santoso, Laura, Hofmann, Simone, Jeschke, Udo, Hutter, Stefan
Format:	Online
Language:	English
Published:	MDPI 2016
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4881470/

id	pubmed-4881470
recordtype	oai_dc
spelling	pubmed-48814702016-05-27 Prototype and Chimera-Type Galectins in Placentas with Spontaneous and Recurrent Miscarriages Unverdorben, Laura Haufe, Thomas Santoso, Laura Hofmann, Simone Jeschke, Udo Hutter, Stefan Article Galectins are galactose binding proteins and, in addition, factors for a wide range of pathologies in pregnancy. We have analyzed the expression of prototype (gal-1, -2, -7, -10) and chimera-type (gal-3) galectins in the placenta in cases of spontaneous abortions (SPA) and recurrent abortions (RA) in the first trimester. Fifteen placental samples from healthy pregnancies were used as a control group. Nine placentas were examined for spontaneous abortions, and 12 placentas for recurrent abortions. For differentiation and evaluation of different cell types of galectin-expression in the decidua, immunofluorescence was used. For all investigated prototype galectins (gal-1, -2, -7, -10) in SPA and RA placenta trophoblast cells the expression is significantly decreased. In the decidua/extravillous trophoblast only gal-2 expression was significantly lowered, which could be connected to its role in angiogenesis. In trophoblasts in first-trimester placentas and in cases of SPA and RA, prototype galectins are altered in the same way. We suspect prototype galectins have a similar function in placental tissue because of their common biochemical structure. Expression of galectin 3 as a chimera type galectin was not found to be significantly altered in abortive placentas. MDPI 2016-04-28 /pmc/articles/PMC4881470/ /pubmed/27136536 http://dx.doi.org/10.3390/ijms17050644 Text en © 2016 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/).
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Unverdorben, Laura Haufe, Thomas Santoso, Laura Hofmann, Simone Jeschke, Udo Hutter, Stefan
spellingShingle	Unverdorben, Laura Haufe, Thomas Santoso, Laura Hofmann, Simone Jeschke, Udo Hutter, Stefan Prototype and Chimera-Type Galectins in Placentas with Spontaneous and Recurrent Miscarriages
author_facet	Unverdorben, Laura Haufe, Thomas Santoso, Laura Hofmann, Simone Jeschke, Udo Hutter, Stefan
author_sort	Unverdorben, Laura
title	Prototype and Chimera-Type Galectins in Placentas with Spontaneous and Recurrent Miscarriages
title_short	Prototype and Chimera-Type Galectins in Placentas with Spontaneous and Recurrent Miscarriages
title_full	Prototype and Chimera-Type Galectins in Placentas with Spontaneous and Recurrent Miscarriages
title_fullStr	Prototype and Chimera-Type Galectins in Placentas with Spontaneous and Recurrent Miscarriages
title_full_unstemmed	Prototype and Chimera-Type Galectins in Placentas with Spontaneous and Recurrent Miscarriages
title_sort	prototype and chimera-type galectins in placentas with spontaneous and recurrent miscarriages
description	Galectins are galactose binding proteins and, in addition, factors for a wide range of pathologies in pregnancy. We have analyzed the expression of prototype (gal-1, -2, -7, -10) and chimera-type (gal-3) galectins in the placenta in cases of spontaneous abortions (SPA) and recurrent abortions (RA) in the first trimester. Fifteen placental samples from healthy pregnancies were used as a control group. Nine placentas were examined for spontaneous abortions, and 12 placentas for recurrent abortions. For differentiation and evaluation of different cell types of galectin-expression in the decidua, immunofluorescence was used. For all investigated prototype galectins (gal-1, -2, -7, -10) in SPA and RA placenta trophoblast cells the expression is significantly decreased. In the decidua/extravillous trophoblast only gal-2 expression was significantly lowered, which could be connected to its role in angiogenesis. In trophoblasts in first-trimester placentas and in cases of SPA and RA, prototype galectins are altered in the same way. We suspect prototype galectins have a similar function in placental tissue because of their common biochemical structure. Expression of galectin 3 as a chimera type galectin was not found to be significantly altered in abortive placentas.
publisher	MDPI
publishDate	2016
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4881470/
_version_	1613584632762073088

Prototype and Chimera-Type Galectins in Placentas with Spontaneous and Recurrent Miscarriages

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