lncRNA/MicroRNA interactions in the vasculature

MicroRNA (miRNA) have gained widespread attention for their role in diverse vascular processes including angiogenesis, apoptosis, proliferation, and migration. Despite great understanding of miRNA expression and function, knowledge of long noncoding RNA (lncRNA) molecular mechanisms still remains li...

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Main Authors:	Ballantyne, MD, McDonald, RA, Baker, AH
Format:	Online
Language:	English
Published:	John Wiley and Sons Inc. 2016
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4881297/

id	pubmed-4881297
recordtype	oai_dc
spelling	pubmed-48812972016-06-27 lncRNA/MicroRNA interactions in the vasculature Ballantyne, MD McDonald, RA Baker, AH State of the Art MicroRNA (miRNA) have gained widespread attention for their role in diverse vascular processes including angiogenesis, apoptosis, proliferation, and migration. Despite great understanding of miRNA expression and function, knowledge of long noncoding RNA (lncRNA) molecular mechanisms still remains limited. The influence of miRNA on lncRNA function, and the converse, is now beginning to emerge. lncRNA may regulate miRNA function by acting as endogenous sponges to regulate gene expression and miRNA have been shown to bind and regulate lncRNA stability. A detailed understanding of the molecular and cellular effects of lncRNA‐miRNA‐mediated interactions in vascular pathophysiology could pave the way for new diagnostic markers and therapeutic approaches, but first there is a requirement for a more detailed understanding of the impact of such regulatory networks. John Wiley and Sons Inc. 2016-03-31 2016-05 /pmc/articles/PMC4881297/ /pubmed/26910520 http://dx.doi.org/10.1002/cpt.355 Text en © 2016 The Authors. Clinical Pharmacology & Therapeutics published by Wiley Periodicals, Inc. on behalf of American Society for Clinical Pharmacology and Therapeutics This is an open access article under the terms of the Creative Commons Attribution (http://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Ballantyne, MD McDonald, RA Baker, AH
spellingShingle	Ballantyne, MD McDonald, RA Baker, AH lncRNA/MicroRNA interactions in the vasculature
author_facet	Ballantyne, MD McDonald, RA Baker, AH
author_sort	Ballantyne, MD
title	lncRNA/MicroRNA interactions in the vasculature
title_short	lncRNA/MicroRNA interactions in the vasculature
title_full	lncRNA/MicroRNA interactions in the vasculature
title_fullStr	lncRNA/MicroRNA interactions in the vasculature
title_full_unstemmed	lncRNA/MicroRNA interactions in the vasculature
title_sort	lncrna/microrna interactions in the vasculature
description	MicroRNA (miRNA) have gained widespread attention for their role in diverse vascular processes including angiogenesis, apoptosis, proliferation, and migration. Despite great understanding of miRNA expression and function, knowledge of long noncoding RNA (lncRNA) molecular mechanisms still remains limited. The influence of miRNA on lncRNA function, and the converse, is now beginning to emerge. lncRNA may regulate miRNA function by acting as endogenous sponges to regulate gene expression and miRNA have been shown to bind and regulate lncRNA stability. A detailed understanding of the molecular and cellular effects of lncRNA‐miRNA‐mediated interactions in vascular pathophysiology could pave the way for new diagnostic markers and therapeutic approaches, but first there is a requirement for a more detailed understanding of the impact of such regulatory networks.
publisher	John Wiley and Sons Inc.
publishDate	2016
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4881297/
_version_	1613584574975049728

lncRNA/MicroRNA interactions in the vasculature

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