Increased diet-induced fatty streak formation in female mice with deficiency of liver-derived insulin-like growth factor-I

Increased diet-induced fatty streak formation in female mice with deficiency of liver-derived insulin-like growth factor-I

The role of endocrine IGF-I for atherosclerosis is unclear. We determined the importance of circulating, liver-derived IGF-I for fatty streak formation in mice. Mice with adult, liver-specific IGF-I inactivation (LI-IGF-I−/− mice, serum IGF-I reduced by approximately 80 %) and control mice received...

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Bibliographic Details
Main Authors: Svensson, Johan, Sjögren, Klara, Levin, Malin, Borén, Jan, Tivesten, Åsa, Ohlsson, Claes
Format: Online
Language:English
Published: Springer US 2015
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4879167/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4879167/

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