Nuclear pore complex remodeling by p75NTR cleavage controls TGF-β signaling and astrocyte functions

Nuclear pore complex remodeling by p75NTR cleavage controls TGF-β signaling and astrocyte functions

Astrocytes play critical roles in neuronal activity and inhibition of regeneration. Here we show that the cleaved p75 neurotrophin receptor (p75NTR) is a component of the nuclear pore complex (NPC) required for glial scar formation and reduced gamma oscillations in mice via regulation of TGF-β signa...

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Bibliographic Details
Main Authors: Schachtrup, Christian, Ryu, Jae Kyu, Mammadzada, Könül, Khan, Abdullah S., Carlton, Peter M., Perez, Alex, Christian, Frank, Le Moan, Natacha, Vagena, Eirini, Baeza-Raja, Bernat, Rafalski, Victoria, Chan, Justin P., Nitschke, Roland, Houslay, Miles D., Ellisman, Mark H., Wyss-Coray, Tony, Palop, Jorge J., Akassoglou, Katerina
Format: Online
Language:English
Published: 2015
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4878404/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4878404/

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