Radioactive Nanomaterials for Multimodality Imaging

Nuclear imaging techniques, primarily including positron emission tomography and single-photon emission computed tomography, can provide quantitative information for a biological event in vivo with ultrahigh sensitivity; however, the comparatively low spatial resolution is their major limitation in...

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Main Authors:	Chen, Daiqin, Dougherty, Casey A., Yang, Dongzhi, Wu, Hongwei, Hong, Hao
Format:	Online
Language:	English
Published:	Grapho Publications, LLC 2016
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4876975/

id	pubmed-4876975
recordtype	oai_dc
spelling	pubmed-48769752016-05-23 Radioactive Nanomaterials for Multimodality Imaging Chen, Daiqin Dougherty, Casey A. Yang, Dongzhi Wu, Hongwei Hong, Hao Review Article Nuclear imaging techniques, primarily including positron emission tomography and single-photon emission computed tomography, can provide quantitative information for a biological event in vivo with ultrahigh sensitivity; however, the comparatively low spatial resolution is their major limitation in clinical application. With the convergence of nuclear imaging with other imaging modalities like computed tomography, magnetic resonance imaging, and optical imaging, the hybrid imaging platforms can overcome the limitations of each individual imaging technique. Possessing versatile chemical linking ability and good cargo-loading capacity, radioactive nanomaterials can serve as ideal imaging contrast agents. Here, we provide a brief overview about the current state-of-the-art applications of radioactive nanomaterials in multimodality imaging. We present strategies for incorporation of radioisotope(s) into nanomaterials with the applications of radioactive nanomaterials in multimodal imaging. Advantages and limitations of radioactive nanomaterials for multimodal imaging applications are discussed. Finally, a future perspective of possible radioactive nanomaterial utilization is presented for improving diagnosis and patient management in a variety of diseases. Grapho Publications, LLC 2016-03 /pmc/articles/PMC4876975/ /pubmed/27227167 http://dx.doi.org/10.18383/j.tom.2016.00121 Text en © 2016 The Authors. Published by Grapho Publications, LLC http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Chen, Daiqin Dougherty, Casey A. Yang, Dongzhi Wu, Hongwei Hong, Hao
spellingShingle	Chen, Daiqin Dougherty, Casey A. Yang, Dongzhi Wu, Hongwei Hong, Hao Radioactive Nanomaterials for Multimodality Imaging
author_facet	Chen, Daiqin Dougherty, Casey A. Yang, Dongzhi Wu, Hongwei Hong, Hao
author_sort	Chen, Daiqin
title	Radioactive Nanomaterials for Multimodality Imaging
title_short	Radioactive Nanomaterials for Multimodality Imaging
title_full	Radioactive Nanomaterials for Multimodality Imaging
title_fullStr	Radioactive Nanomaterials for Multimodality Imaging
title_full_unstemmed	Radioactive Nanomaterials for Multimodality Imaging
title_sort	radioactive nanomaterials for multimodality imaging
description	Nuclear imaging techniques, primarily including positron emission tomography and single-photon emission computed tomography, can provide quantitative information for a biological event in vivo with ultrahigh sensitivity; however, the comparatively low spatial resolution is their major limitation in clinical application. With the convergence of nuclear imaging with other imaging modalities like computed tomography, magnetic resonance imaging, and optical imaging, the hybrid imaging platforms can overcome the limitations of each individual imaging technique. Possessing versatile chemical linking ability and good cargo-loading capacity, radioactive nanomaterials can serve as ideal imaging contrast agents. Here, we provide a brief overview about the current state-of-the-art applications of radioactive nanomaterials in multimodality imaging. We present strategies for incorporation of radioisotope(s) into nanomaterials with the applications of radioactive nanomaterials in multimodal imaging. Advantages and limitations of radioactive nanomaterials for multimodal imaging applications are discussed. Finally, a future perspective of possible radioactive nanomaterial utilization is presented for improving diagnosis and patient management in a variety of diseases.
publisher	Grapho Publications, LLC
publishDate	2016
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4876975/
_version_	1613582886660734976

Radioactive Nanomaterials for Multimodality Imaging

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