ATP-Responsive and Near-Infrared-Emissive Nanocarriers for Anticancer Drug Delivery and Real-Time Imaging

Stimuli-responsive and imaging-guided drug delivery systems hold vast promise for enhancement of therapeutic efficacy. Here we report an adenosine-5'-triphosphate (ATP)-responsive and near-infrared (NIR)-emissive conjugated polymer-based nanocarrier for the controlled release of anticancer drug...

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Main Authors:	Qian, Chenggen, Chen, Yulei, Zhu, Sha, Yu, Jicheng, Zhang, Lei, Feng, Peijian, Tang, Xin, Hu, Quanyin, Sun, Wujin, Lu, Yue, Xiao, Xuanzhong, Shen, Qun-Dong, Gu, Zhen
Format:	Online
Language:	English
Published:	Ivyspring International Publisher 2016
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4876629/

id	pubmed-4876629
recordtype	oai_dc
spelling	pubmed-48766292016-05-23 ATP-Responsive and Near-Infrared-Emissive Nanocarriers for Anticancer Drug Delivery and Real-Time Imaging Qian, Chenggen Chen, Yulei Zhu, Sha Yu, Jicheng Zhang, Lei Feng, Peijian Tang, Xin Hu, Quanyin Sun, Wujin Lu, Yue Xiao, Xuanzhong Shen, Qun-Dong Gu, Zhen Research Paper Stimuli-responsive and imaging-guided drug delivery systems hold vast promise for enhancement of therapeutic efficacy. Here we report an adenosine-5'-triphosphate (ATP)-responsive and near-infrared (NIR)-emissive conjugated polymer-based nanocarrier for the controlled release of anticancer drugs and real-time imaging. We demonstrate that the conjugated polymeric nanocarriers functionalized with phenylboronic acid tags on surface as binding sites for ATP could be converted to the water-soluble conjugated polyelectrolytes in an ATP-rich environment, which promotes the disassembly of the drug carrier and subsequent release of the cargo. In vivo studies validate that this formulation exhibits promising capability for inhibition of tumor growth. We also evaluate the metabolism process by monitoring the fluorescence signal of the conjugated polymer through the in vivo NIR imaging. Ivyspring International Publisher 2016-04-28 /pmc/articles/PMC4876629/ /pubmed/27217838 http://dx.doi.org/10.7150/thno.14843 Text en © Ivyspring International Publisher. Reproduction is permitted for personal, noncommercial use, provided that the article is in whole, unmodified, and properly cited. See http://ivyspring.com/terms for terms and conditions.
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Qian, Chenggen Chen, Yulei Zhu, Sha Yu, Jicheng Zhang, Lei Feng, Peijian Tang, Xin Hu, Quanyin Sun, Wujin Lu, Yue Xiao, Xuanzhong Shen, Qun-Dong Gu, Zhen
spellingShingle	Qian, Chenggen Chen, Yulei Zhu, Sha Yu, Jicheng Zhang, Lei Feng, Peijian Tang, Xin Hu, Quanyin Sun, Wujin Lu, Yue Xiao, Xuanzhong Shen, Qun-Dong Gu, Zhen ATP-Responsive and Near-Infrared-Emissive Nanocarriers for Anticancer Drug Delivery and Real-Time Imaging
author_facet	Qian, Chenggen Chen, Yulei Zhu, Sha Yu, Jicheng Zhang, Lei Feng, Peijian Tang, Xin Hu, Quanyin Sun, Wujin Lu, Yue Xiao, Xuanzhong Shen, Qun-Dong Gu, Zhen
author_sort	Qian, Chenggen
title	ATP-Responsive and Near-Infrared-Emissive Nanocarriers for Anticancer Drug Delivery and Real-Time Imaging
title_short	ATP-Responsive and Near-Infrared-Emissive Nanocarriers for Anticancer Drug Delivery and Real-Time Imaging
title_full	ATP-Responsive and Near-Infrared-Emissive Nanocarriers for Anticancer Drug Delivery and Real-Time Imaging
title_fullStr	ATP-Responsive and Near-Infrared-Emissive Nanocarriers for Anticancer Drug Delivery and Real-Time Imaging
title_full_unstemmed	ATP-Responsive and Near-Infrared-Emissive Nanocarriers for Anticancer Drug Delivery and Real-Time Imaging
title_sort	atp-responsive and near-infrared-emissive nanocarriers for anticancer drug delivery and real-time imaging
description	Stimuli-responsive and imaging-guided drug delivery systems hold vast promise for enhancement of therapeutic efficacy. Here we report an adenosine-5'-triphosphate (ATP)-responsive and near-infrared (NIR)-emissive conjugated polymer-based nanocarrier for the controlled release of anticancer drugs and real-time imaging. We demonstrate that the conjugated polymeric nanocarriers functionalized with phenylboronic acid tags on surface as binding sites for ATP could be converted to the water-soluble conjugated polyelectrolytes in an ATP-rich environment, which promotes the disassembly of the drug carrier and subsequent release of the cargo. In vivo studies validate that this formulation exhibits promising capability for inhibition of tumor growth. We also evaluate the metabolism process by monitoring the fluorescence signal of the conjugated polymer through the in vivo NIR imaging.
publisher	Ivyspring International Publisher
publishDate	2016
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4876629/
_version_	1613582766730903552

ATP-Responsive and Near-Infrared-Emissive Nanocarriers for Anticancer Drug Delivery and Real-Time Imaging

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