β-Catenin Stabilization in Skin Fibroblasts Causes Fibrotic Lesions by Preventing Adipocyte Differentiation of the Reticular Dermis

β-Catenin Stabilization in Skin Fibroblasts Causes Fibrotic Lesions by Preventing Adipocyte Differentiation of the Reticular Dermis

The Wnt/β-catenin pathway plays a central role in epidermal homeostasis and regeneration, but how it affects fibroblast fate decisions is unknown. We investigated the effect of targeted β-catenin stabilization in dermal fibroblasts. Comparative gene expression profiling of stem cell antigen 1- (Sca1...

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Bibliographic Details
Main Authors: Mastrogiannaki, Maria, Lichtenberger, Beate M., Reimer, Andreas, Collins, Charlotte A., Driskell, Ryan R., Watt, Fiona M.
Format: Online
Language:English
Published: Elsevier 2016
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4874948/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4874948/

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