Anti-tumor effect of bevacizumab on a xenograft model of feline mammary carcinoma

Anti-tumor effect of bevacizumab on a xenograft model of feline mammary carcinoma

Feline mammary carcinomas are characterized by rapid progression and metastases. Vascular endothelial growth factor (VEGF) is a key regulator of tumor angiogenesis, proliferation and metastasis. The present study aimed to investigate the effects of a single drug therapy of bevacizumab on a xenograft...

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Main Authors: MICHISHITA, Masaki, OHTSUKA, Aya, NAKAHIRA, Rei, TAJIMA, Tsuyoshi, NAKAGAWA, Takayuki, SASAKI, Nobuo, ARAI, Toshiro, TAKAHASHI, Kimimasa
Format: Online
Language:English
Published: The Japanese Society of Veterinary Science 2015
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4873862/
id pubmed-4873862
recordtype oai_dc
spelling pubmed-48738622016-05-25 Anti-tumor effect of bevacizumab on a xenograft model of feline mammary carcinoma MICHISHITA, Masaki OHTSUKA, Aya NAKAHIRA, Rei TAJIMA, Tsuyoshi NAKAGAWA, Takayuki SASAKI, Nobuo ARAI, Toshiro TAKAHASHI, Kimimasa Pharmacology Feline mammary carcinomas are characterized by rapid progression and metastases. Vascular endothelial growth factor (VEGF) is a key regulator of tumor angiogenesis, proliferation and metastasis. The present study aimed to investigate the effects of a single drug therapy of bevacizumab on a xenograft model of feline mammary carcinoma expressing VEGF protein. Bevacizumab treatment suppressed tumor growth by inhibiting angiogenesis and enhancing apoptosis; however, it did not affect the tumor proliferation index. Thus, bevacizumab had anti-tumor effects on a xenograft model, and this may be useful for the treatment of feline mammary carcinoma. The Japanese Society of Veterinary Science 2015-11-28 2016-04 /pmc/articles/PMC4873862/ /pubmed/26616000 http://dx.doi.org/10.1292/jvms.15-0550 Text en ©2016 The Japanese Society of Veterinary Science http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial No Derivatives (by-nc-nd) License.
repository_type Open Access Journal
institution_category Foreign Institution
institution US National Center for Biotechnology Information
building NCBI PubMed
collection Online Access
language English
format Online
author MICHISHITA, Masaki
OHTSUKA, Aya
NAKAHIRA, Rei
TAJIMA, Tsuyoshi
NAKAGAWA, Takayuki
SASAKI, Nobuo
ARAI, Toshiro
TAKAHASHI, Kimimasa
spellingShingle MICHISHITA, Masaki
OHTSUKA, Aya
NAKAHIRA, Rei
TAJIMA, Tsuyoshi
NAKAGAWA, Takayuki
SASAKI, Nobuo
ARAI, Toshiro
TAKAHASHI, Kimimasa
Anti-tumor effect of bevacizumab on a xenograft model of feline mammary carcinoma
author_facet MICHISHITA, Masaki
OHTSUKA, Aya
NAKAHIRA, Rei
TAJIMA, Tsuyoshi
NAKAGAWA, Takayuki
SASAKI, Nobuo
ARAI, Toshiro
TAKAHASHI, Kimimasa
author_sort MICHISHITA, Masaki
title Anti-tumor effect of bevacizumab on a xenograft model of feline mammary carcinoma
title_short Anti-tumor effect of bevacizumab on a xenograft model of feline mammary carcinoma
title_full Anti-tumor effect of bevacizumab on a xenograft model of feline mammary carcinoma
title_fullStr Anti-tumor effect of bevacizumab on a xenograft model of feline mammary carcinoma
title_full_unstemmed Anti-tumor effect of bevacizumab on a xenograft model of feline mammary carcinoma
title_sort anti-tumor effect of bevacizumab on a xenograft model of feline mammary carcinoma
description Feline mammary carcinomas are characterized by rapid progression and metastases. Vascular endothelial growth factor (VEGF) is a key regulator of tumor angiogenesis, proliferation and metastasis. The present study aimed to investigate the effects of a single drug therapy of bevacizumab on a xenograft model of feline mammary carcinoma expressing VEGF protein. Bevacizumab treatment suppressed tumor growth by inhibiting angiogenesis and enhancing apoptosis; however, it did not affect the tumor proliferation index. Thus, bevacizumab had anti-tumor effects on a xenograft model, and this may be useful for the treatment of feline mammary carcinoma.
publisher The Japanese Society of Veterinary Science
publishDate 2015
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4873862/
_version_ 1613581951274319872

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