A significant causal association between C-reactive protein levels and schizophrenia
Many observational studies have shown elevated blood CRP levels in schizophrenia compared with controls, and one population-based prospective study has reported that elevated plasma CRP levels were associated with late- and very-late-onset schizophrenia. Furthermore, several clinical studies have re...
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Nature Publishing Group
2016
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4872134/ |
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pubmed-48721342016-06-01 A significant causal association between C-reactive protein levels and schizophrenia Inoshita, Masatoshi Numata, Shusuke Tajima, Atsushi Kinoshita, Makoto Umehara, Hidehiro Nakataki, Masahito Ikeda, Masashi Maruyama, Souichiro Yamamori, Hidenaga Kanazawa, Tetsufumi Shimodera, Shinji Hashimoto, Ryota Imoto, Issei Yoneda, Hiroshi Iwata, Nakao Ohmori, Tetsuro Article Many observational studies have shown elevated blood CRP levels in schizophrenia compared with controls, and one population-based prospective study has reported that elevated plasma CRP levels were associated with late- and very-late-onset schizophrenia. Furthermore, several clinical studies have reported the efficacy of anti-inflammatory drugs on the symptoms in patients with schizophrenia. However, whether elevated CRP levels are causally related to schizophrenia is not still established because of confounding factors and reverse causality. In the present study, we demonstrated that serum CRP levels were significantly higher in patients with schizophrenia than in the controls by conducting a case-control study and a meta-analysis of case-control studies between schizophrenia and serum CRP levels. Furthermore, we provided evidence for a causal association between elevated CRP levels and increased schizophrenia risk by conducting a Mendelian randomization analysis. Our findings suggest that elevated CRP itself may be a causal risk factor for schizophrenia. Nature Publishing Group 2016-05-19 /pmc/articles/PMC4872134/ /pubmed/27193331 http://dx.doi.org/10.1038/srep26105 Text en Copyright © 2016, Macmillan Publishers Limited http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ |
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Open Access Journal |
| institution_category |
Foreign Institution |
| institution |
US National Center for Biotechnology Information |
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NCBI PubMed |
| collection |
Online Access |
| language |
English |
| format |
Online |
| author |
Inoshita, Masatoshi Numata, Shusuke Tajima, Atsushi Kinoshita, Makoto Umehara, Hidehiro Nakataki, Masahito Ikeda, Masashi Maruyama, Souichiro Yamamori, Hidenaga Kanazawa, Tetsufumi Shimodera, Shinji Hashimoto, Ryota Imoto, Issei Yoneda, Hiroshi Iwata, Nakao Ohmori, Tetsuro |
| spellingShingle |
Inoshita, Masatoshi Numata, Shusuke Tajima, Atsushi Kinoshita, Makoto Umehara, Hidehiro Nakataki, Masahito Ikeda, Masashi Maruyama, Souichiro Yamamori, Hidenaga Kanazawa, Tetsufumi Shimodera, Shinji Hashimoto, Ryota Imoto, Issei Yoneda, Hiroshi Iwata, Nakao Ohmori, Tetsuro A significant causal association between C-reactive protein levels and schizophrenia |
| author_facet |
Inoshita, Masatoshi Numata, Shusuke Tajima, Atsushi Kinoshita, Makoto Umehara, Hidehiro Nakataki, Masahito Ikeda, Masashi Maruyama, Souichiro Yamamori, Hidenaga Kanazawa, Tetsufumi Shimodera, Shinji Hashimoto, Ryota Imoto, Issei Yoneda, Hiroshi Iwata, Nakao Ohmori, Tetsuro |
| author_sort |
Inoshita, Masatoshi |
| title |
A significant causal association between C-reactive protein levels and schizophrenia |
| title_short |
A significant causal association between C-reactive protein levels and schizophrenia |
| title_full |
A significant causal association between C-reactive protein levels and schizophrenia |
| title_fullStr |
A significant causal association between C-reactive protein levels and schizophrenia |
| title_full_unstemmed |
A significant causal association between C-reactive protein levels and schizophrenia |
| title_sort |
significant causal association between c-reactive protein levels and schizophrenia |
| description |
Many observational studies have shown elevated blood CRP levels in schizophrenia compared with controls, and one population-based prospective study has reported that elevated plasma CRP levels were associated with late- and very-late-onset schizophrenia. Furthermore, several clinical studies have reported the efficacy of anti-inflammatory drugs on the symptoms in patients with schizophrenia. However, whether elevated CRP levels are causally related to schizophrenia is not still established because of confounding factors and reverse causality. In the present study, we demonstrated that serum CRP levels were significantly higher in patients with schizophrenia than in the controls by conducting a case-control study and a meta-analysis of case-control studies between schizophrenia and serum CRP levels. Furthermore, we provided evidence for a causal association between elevated CRP levels and increased schizophrenia risk by conducting a Mendelian randomization analysis. Our findings suggest that elevated CRP itself may be a causal risk factor for schizophrenia. |
| publisher |
Nature Publishing Group |
| publishDate |
2016 |
| url |
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4872134/ |
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1613581215075401728 |