Network science for the identification of novel therapeutic targets in epilepsy
The quality of life of children with epilepsy is a function of seizures and associated cognitive and behavioral comorbidities. Current treatments are not successful at stopping seizures in approximately 30% of patients despite the introduction of multiple new antiepileptic drugs over the last decade...
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| Format: | Online |
| Language: | English |
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F1000Research
2016
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4870991/ |
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pubmed-4870991 |
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pubmed-48709912016-05-26 Network science for the identification of novel therapeutic targets in epilepsy Scott, Rod C. Review The quality of life of children with epilepsy is a function of seizures and associated cognitive and behavioral comorbidities. Current treatments are not successful at stopping seizures in approximately 30% of patients despite the introduction of multiple new antiepileptic drugs over the last decade. In addition, modification of seizures has only a modest impact on the comorbidities. Therefore, novel approaches to identify therapeutic targets that improve seizures and comorbidities are urgently required. The potential of network science as applied to genetic, local neural network, and global brain data is reviewed. Several examples of possible new therapeutic approaches defined using novel network tools are highlighted. Further study to translate the findings into clinical practice is now required. F1000Research 2016-05-16 /pmc/articles/PMC4870991/ /pubmed/27239287 http://dx.doi.org/10.12688/f1000research.8214.1 Text en Copyright: © 2016 Scott RC http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
| repository_type |
Open Access Journal |
| institution_category |
Foreign Institution |
| institution |
US National Center for Biotechnology Information |
| building |
NCBI PubMed |
| collection |
Online Access |
| language |
English |
| format |
Online |
| author |
Scott, Rod C. |
| spellingShingle |
Scott, Rod C. Network science for the identification of novel therapeutic targets in epilepsy |
| author_facet |
Scott, Rod C. |
| author_sort |
Scott, Rod C. |
| title |
Network science for the identification of novel therapeutic targets in epilepsy |
| title_short |
Network science for the identification of novel therapeutic targets in epilepsy |
| title_full |
Network science for the identification of novel therapeutic targets in epilepsy |
| title_fullStr |
Network science for the identification of novel therapeutic targets in epilepsy |
| title_full_unstemmed |
Network science for the identification of novel therapeutic targets in epilepsy |
| title_sort |
network science for the identification of novel therapeutic targets in epilepsy |
| description |
The quality of life of children with epilepsy is a function of seizures and associated cognitive and behavioral comorbidities. Current treatments are not successful at stopping seizures in approximately 30% of patients despite the introduction of multiple new antiepileptic drugs over the last decade. In addition, modification of seizures has only a modest impact on the comorbidities. Therefore, novel approaches to identify therapeutic targets that improve seizures and comorbidities are urgently required. The potential of network science as applied to genetic, local neural network, and global brain data is reviewed. Several examples of possible new therapeutic approaches defined using novel network tools are highlighted. Further study to translate the findings into clinical practice is now required. |
| publisher |
F1000Research |
| publishDate |
2016 |
| url |
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4870991/ |
| _version_ |
1613580805835063296 |