TSPO imaging in parkinsonian disorders
Microglial activation is a key aspect of the neuroinflammatory process in neurodegenerative disorders including idiopathic and atypical parkinsonian disorders. With positron emission tomography (PET) it has become possible to image this phenomenon in vivo and over the last years patterns of microgli...
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| Format: | Online |
| Language: | English |
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Springer Milan
2016
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4870295/ |
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pubmed-48702952016-06-21 TSPO imaging in parkinsonian disorders Gerhard, Alexander Review Article Microglial activation is a key aspect of the neuroinflammatory process in neurodegenerative disorders including idiopathic and atypical parkinsonian disorders. With positron emission tomography (PET) it has become possible to image this phenomenon in vivo and over the last years patterns of microglia activation corresponding with the known distribution of neuropathological changes in these disorders have been demonstrated using this technique. In addition the effects of interventions aimed at suppressing microglia activation as part of interventional trials have successfully been demonstrated. Current research aims at evaluating PET tracers for microglial activation with more favorable properties than the prototypical [11C]-(R)-PK11195, as well as developing tracers targeting additional parameters of the neuroinflammatory process like astroglial function. Springer Milan 2016-04-11 2016 /pmc/articles/PMC4870295/ /pubmed/27340650 http://dx.doi.org/10.1007/s40336-016-0171-1 Text en © The Author(s) 2016 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. |
| repository_type |
Open Access Journal |
| institution_category |
Foreign Institution |
| institution |
US National Center for Biotechnology Information |
| building |
NCBI PubMed |
| collection |
Online Access |
| language |
English |
| format |
Online |
| author |
Gerhard, Alexander |
| spellingShingle |
Gerhard, Alexander TSPO imaging in parkinsonian disorders |
| author_facet |
Gerhard, Alexander |
| author_sort |
Gerhard, Alexander |
| title |
TSPO imaging in parkinsonian disorders |
| title_short |
TSPO imaging in parkinsonian disorders |
| title_full |
TSPO imaging in parkinsonian disorders |
| title_fullStr |
TSPO imaging in parkinsonian disorders |
| title_full_unstemmed |
TSPO imaging in parkinsonian disorders |
| title_sort |
tspo imaging in parkinsonian disorders |
| description |
Microglial activation is a key aspect of the neuroinflammatory process in neurodegenerative disorders including idiopathic and atypical parkinsonian disorders. With positron emission tomography (PET) it has become possible to image this phenomenon in vivo and over the last years patterns of microglia activation corresponding with the known distribution of neuropathological changes in these disorders have been demonstrated using this technique. In addition the effects of interventions aimed at suppressing microglia activation as part of interventional trials have successfully been demonstrated. Current research aims at evaluating PET tracers for microglial activation with more favorable properties than the prototypical [11C]-(R)-PK11195, as well as developing tracers targeting additional parameters of the neuroinflammatory process like astroglial function. |
| publisher |
Springer Milan |
| publishDate |
2016 |
| url |
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4870295/ |
| _version_ |
1613580480004751360 |