Altered mean platelet volume in patients with polymyositis and its association with disease severity
Polymyositis (PM) is an autoimmune disease characterized by chronic inflammation in skeletal muscle. Mean platelet volume (MPV), a marker in the assessment of systemic inflammation, is easily measured by automatic blood count equipment. However, to our knowledge, there are no data in the literature...
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Associação Brasileira de Divulgação Científica
2016
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4869824/ |
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pubmed-48698242016-06-01 Altered mean platelet volume in patients with polymyositis and its association with disease severity Peng, Y.-F. Huang, Y.-X. Wei, Y.-S. Clinical Investigation Polymyositis (PM) is an autoimmune disease characterized by chronic inflammation in skeletal muscle. Mean platelet volume (MPV), a marker in the assessment of systemic inflammation, is easily measured by automatic blood count equipment. However, to our knowledge, there are no data in the literature with respect to MPV levels in PM patients. Therefore, in this study we aimed to investigate MPV levels in patients with PM. This study included 92 newly diagnosed PM patients and 100 healthy individuals. MPV levels were found to be significantly lower compared with healthy controls (10.3±1.23 vs 11.5±0.74 fL, P<0.001). Interestingly, MPV was found to be positively correlated with manual muscle test (MMT) score and negatively correlated with erythrocyte sedimentation rate (ESR) in patients with PM (r=0.239, P=0.022; r=−0.268, P=0.010, respectively). In addition, MPV was significantly lower in active PM patients compared with inactive PM patients (9.9±1.39 vs 10.6±0.92 fL, P=0.010). MPV was independently associated with PM in multivariate regression analyses, when controlling for hemoglobin and ESR (OR=0.312, P=0.031, 95%CI=0.108 to 0.899). The ROC curve analysis for MPV in estimating PM patients resulted in an area under the curve of 0.800, with sensitivity of 75.0% and specificity of 67.4%. Our results suggest that MPV is inversely correlated with disease activity in patients with PM. MPV might be a useful tool for rapid assessment of disease severity in PM patients. Associação Brasileira de Divulgação Científica 2016-05-13 /pmc/articles/PMC4869824/ /pubmed/27191605 http://dx.doi.org/10.1590/1414-431X20165168 Text en http://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
| repository_type |
Open Access Journal |
| institution_category |
Foreign Institution |
| institution |
US National Center for Biotechnology Information |
| building |
NCBI PubMed |
| collection |
Online Access |
| language |
English |
| format |
Online |
| author |
Peng, Y.-F. Huang, Y.-X. Wei, Y.-S. |
| spellingShingle |
Peng, Y.-F. Huang, Y.-X. Wei, Y.-S. Altered mean platelet volume in patients with polymyositis and its association with disease severity |
| author_facet |
Peng, Y.-F. Huang, Y.-X. Wei, Y.-S. |
| author_sort |
Peng, Y.-F. |
| title |
Altered mean platelet volume in patients with polymyositis and its
association with disease severity |
| title_short |
Altered mean platelet volume in patients with polymyositis and its
association with disease severity |
| title_full |
Altered mean platelet volume in patients with polymyositis and its
association with disease severity |
| title_fullStr |
Altered mean platelet volume in patients with polymyositis and its
association with disease severity |
| title_full_unstemmed |
Altered mean platelet volume in patients with polymyositis and its
association with disease severity |
| title_sort |
altered mean platelet volume in patients with polymyositis and its
association with disease severity |
| description |
Polymyositis (PM) is an autoimmune disease characterized by chronic inflammation in
skeletal muscle. Mean platelet volume (MPV), a marker in the assessment of systemic
inflammation, is easily measured by automatic blood count equipment. However, to our
knowledge, there are no data in the literature with respect to MPV levels in PM
patients. Therefore, in this study we aimed to investigate MPV levels in patients
with PM. This study included 92 newly diagnosed PM patients and 100 healthy
individuals. MPV levels were found to be significantly lower compared with healthy
controls (10.3±1.23 vs 11.5±0.74 fL, P<0.001). Interestingly, MPV
was found to be positively correlated with manual muscle test (MMT) score and
negatively correlated with erythrocyte sedimentation rate (ESR) in patients with PM
(r=0.239, P=0.022; r=−0.268, P=0.010, respectively). In addition, MPV was
significantly lower in active PM patients compared with inactive PM patients
(9.9±1.39 vs 10.6±0.92 fL, P=0.010). MPV was independently
associated with PM in multivariate regression analyses, when controlling for
hemoglobin and ESR (OR=0.312, P=0.031, 95%CI=0.108 to 0.899). The ROC curve analysis
for MPV in estimating PM patients resulted in an area under the curve of 0.800, with
sensitivity of 75.0% and specificity of 67.4%. Our results suggest that MPV is
inversely correlated with disease activity in patients with PM. MPV might be a useful
tool for rapid assessment of disease severity in PM patients. |
| publisher |
Associação Brasileira de Divulgação Científica |
| publishDate |
2016 |
| url |
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4869824/ |
| _version_ |
1613580387401859072 |