Regulation of Irregular Neuronal Firing by Autaptic Transmission

The importance of self-feedback autaptic transmission in modulating spike-time irregularity is still poorly understood. By using a biophysical model that incorporates autaptic coupling, we here show that self-innervation of neurons participates in the modulation of irregular neuronal firing, primari...

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Main Authors:	Guo, Daqing, Wu, Shengdun, Chen, Mingming, Perc, Matjaž, Zhang, Yangsong, Ma, Jingling, Cui, Yan, Xu, Peng, Xia, Yang, Yao, Dezhong
Format:	Online
Language:	English
Published:	Nature Publishing Group 2016
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4869121/

id	pubmed-4869121
recordtype	oai_dc
spelling	pubmed-48691212016-06-01 Regulation of Irregular Neuronal Firing by Autaptic Transmission Guo, Daqing Wu, Shengdun Chen, Mingming Perc, Matjaž Zhang, Yangsong Ma, Jingling Cui, Yan Xu, Peng Xia, Yang Yao, Dezhong Article The importance of self-feedback autaptic transmission in modulating spike-time irregularity is still poorly understood. By using a biophysical model that incorporates autaptic coupling, we here show that self-innervation of neurons participates in the modulation of irregular neuronal firing, primarily by regulating the occurrence frequency of burst firing. In particular, we find that both excitatory and electrical autapses increase the occurrence of burst firing, thus reducing neuronal firing regularity. In contrast, inhibitory autapses suppress burst firing and therefore tend to improve the regularity of neuronal firing. Importantly, we show that these findings are independent of the firing properties of individual neurons, and as such can be observed for neurons operating in different modes. Our results provide an insightful mechanistic understanding of how different types of autapses shape irregular firing at the single-neuron level, and they highlight the functional importance of autaptic self-innervation in taming and modulating neurodynamics. Nature Publishing Group 2016-05-17 /pmc/articles/PMC4869121/ /pubmed/27185280 http://dx.doi.org/10.1038/srep26096 Text en Copyright © 2016, Macmillan Publishers Limited http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Guo, Daqing Wu, Shengdun Chen, Mingming Perc, Matjaž Zhang, Yangsong Ma, Jingling Cui, Yan Xu, Peng Xia, Yang Yao, Dezhong
spellingShingle	Guo, Daqing Wu, Shengdun Chen, Mingming Perc, Matjaž Zhang, Yangsong Ma, Jingling Cui, Yan Xu, Peng Xia, Yang Yao, Dezhong Regulation of Irregular Neuronal Firing by Autaptic Transmission
author_facet	Guo, Daqing Wu, Shengdun Chen, Mingming Perc, Matjaž Zhang, Yangsong Ma, Jingling Cui, Yan Xu, Peng Xia, Yang Yao, Dezhong
author_sort	Guo, Daqing
title	Regulation of Irregular Neuronal Firing by Autaptic Transmission
title_short	Regulation of Irregular Neuronal Firing by Autaptic Transmission
title_full	Regulation of Irregular Neuronal Firing by Autaptic Transmission
title_fullStr	Regulation of Irregular Neuronal Firing by Autaptic Transmission
title_full_unstemmed	Regulation of Irregular Neuronal Firing by Autaptic Transmission
title_sort	regulation of irregular neuronal firing by autaptic transmission
description	The importance of self-feedback autaptic transmission in modulating spike-time irregularity is still poorly understood. By using a biophysical model that incorporates autaptic coupling, we here show that self-innervation of neurons participates in the modulation of irregular neuronal firing, primarily by regulating the occurrence frequency of burst firing. In particular, we find that both excitatory and electrical autapses increase the occurrence of burst firing, thus reducing neuronal firing regularity. In contrast, inhibitory autapses suppress burst firing and therefore tend to improve the regularity of neuronal firing. Importantly, we show that these findings are independent of the firing properties of individual neurons, and as such can be observed for neurons operating in different modes. Our results provide an insightful mechanistic understanding of how different types of autapses shape irregular firing at the single-neuron level, and they highlight the functional importance of autaptic self-innervation in taming and modulating neurodynamics.
publisher	Nature Publishing Group
publishDate	2016
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4869121/
_version_	1613580062129389568

Regulation of Irregular Neuronal Firing by Autaptic Transmission

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