Generation and characterization of a tetraspanin CD151/integrin α6β1-binding domain competitively binding monoclonal antibody for inhibition of tumor progression in HCC

Generation and characterization of a tetraspanin CD151/integrin α6β1-binding domain competitively binding monoclonal antibody for inhibition of tumor progression in HCC

Our previous studies revealed that tetraspanin CD151 plays multiple roles in the progression of hepatocellular carcinoma (HCC) by forming a functional complex with integrin α6β1. Herein, we generated a monoclonal antibody (mAb) that dissociates the CD151/integrin α6β1 complex, and we evaluated its b...

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Bibliographic Details
Main Authors: Ke, Ai-Wu, Zhang, Peng-Fei, Shen, Ying-Hao, Gao, Ping-Ting, Dong, Zhao-Ru, Zhang, Chi, Cai, Jia-Bin, Huang, Xiao-Yong, Wu, Chao, Zhang, Lu, Kang, Qiang, Liu, Li-Xin, Xie, Nan, Shen, Zao-Zhuo, Hu, Mei-Yu, Cao, Ya, Qiu, Shuang-Jian, Sun, Hui-Chuan, Zhou, Jian, Fan, Jia, Shi, Guo-Ming
Format: Online
Language:English
Published: Impact Journals LLC 2016
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4868758/

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4868758/

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