Trop2 is overexpressed in gastric cancer and predicts poor prognosis

The cell surface protein Trop2 is overexpressed in a variety of human cancers. Trop2 expression increases tumor development and metastasis and reduces patient survival. However, little is known about the role of Trop2 expression and its prognostic value in gastric cancer (GC), particularly in Chines...

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Main Authors:	Zhao, Wei, Zhu, Huijun, Zhang, Shu, Yong, Hongmei, Wang, Wei, Zhou, Yan, Wang, Bing, Wen, Jinbo, Qiu, Zhenning, Ding, Guipeng, Feng, Zhenqing, Zhu, Jin
Format:	Online
Language:	English
Published:	Impact Journals LLC 2015
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4868745/

id	pubmed-4868745
recordtype	oai_dc
spelling	pubmed-48687452016-05-20 Trop2 is overexpressed in gastric cancer and predicts poor prognosis Zhao, Wei Zhu, Huijun Zhang, Shu Yong, Hongmei Wang, Wei Zhou, Yan Wang, Bing Wen, Jinbo Qiu, Zhenning Ding, Guipeng Feng, Zhenqing Zhu, Jin Research Paper The cell surface protein Trop2 is overexpressed in a variety of human cancers. Trop2 expression increases tumor development and metastasis and reduces patient survival. However, little is known about the role of Trop2 expression and its prognostic value in gastric cancer (GC), particularly in Chinese populations. We analyzed Trop2 expression in GC tissues collected from Chinese GC patients. Quantitative real-time polymerase chain reaction (qRT-PCR) and immunohistochemistry on tissue microarrays were performed to assess levels of Trop2 mRNA and protein in GC, and correlations between Trop2 expression and clinical characteristics and prognosis were analyzed. Trop2 expression was higher in GC tissues than in neighboring non-tumor tissues. Increased Trop2 protein levels in GC were associated with increased differentiation, tumor node metastasis stage, tumor size, lymph node metastasis, distant metastasis, and H. pylori infection. GC patients with high Trop2 expression also had poor overall survival rates. These data suggest Trop2 is a useful prognostic biomarker for GC. Impact Journals LLC 2015-12-22 /pmc/articles/PMC4868745/ /pubmed/26716416 http://dx.doi.org/10.18632/oncotarget.6733 Text en Copyright: © 2016 Zhao et al. http://creativecommons.org/licenses/by/2.5/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Zhao, Wei Zhu, Huijun Zhang, Shu Yong, Hongmei Wang, Wei Zhou, Yan Wang, Bing Wen, Jinbo Qiu, Zhenning Ding, Guipeng Feng, Zhenqing Zhu, Jin
spellingShingle	Zhao, Wei Zhu, Huijun Zhang, Shu Yong, Hongmei Wang, Wei Zhou, Yan Wang, Bing Wen, Jinbo Qiu, Zhenning Ding, Guipeng Feng, Zhenqing Zhu, Jin Trop2 is overexpressed in gastric cancer and predicts poor prognosis
author_facet	Zhao, Wei Zhu, Huijun Zhang, Shu Yong, Hongmei Wang, Wei Zhou, Yan Wang, Bing Wen, Jinbo Qiu, Zhenning Ding, Guipeng Feng, Zhenqing Zhu, Jin
author_sort	Zhao, Wei
title	Trop2 is overexpressed in gastric cancer and predicts poor prognosis
title_short	Trop2 is overexpressed in gastric cancer and predicts poor prognosis
title_full	Trop2 is overexpressed in gastric cancer and predicts poor prognosis
title_fullStr	Trop2 is overexpressed in gastric cancer and predicts poor prognosis
title_full_unstemmed	Trop2 is overexpressed in gastric cancer and predicts poor prognosis
title_sort	trop2 is overexpressed in gastric cancer and predicts poor prognosis
description	The cell surface protein Trop2 is overexpressed in a variety of human cancers. Trop2 expression increases tumor development and metastasis and reduces patient survival. However, little is known about the role of Trop2 expression and its prognostic value in gastric cancer (GC), particularly in Chinese populations. We analyzed Trop2 expression in GC tissues collected from Chinese GC patients. Quantitative real-time polymerase chain reaction (qRT-PCR) and immunohistochemistry on tissue microarrays were performed to assess levels of Trop2 mRNA and protein in GC, and correlations between Trop2 expression and clinical characteristics and prognosis were analyzed. Trop2 expression was higher in GC tissues than in neighboring non-tumor tissues. Increased Trop2 protein levels in GC were associated with increased differentiation, tumor node metastasis stage, tumor size, lymph node metastasis, distant metastasis, and H. pylori infection. GC patients with high Trop2 expression also had poor overall survival rates. These data suggest Trop2 is a useful prognostic biomarker for GC.
publisher	Impact Journals LLC
publishDate	2015
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4868745/
_version_	1613579899583332352

Trop2 is overexpressed in gastric cancer and predicts poor prognosis

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