Altered mGluR5-Homer scaffolds and corticostriatal connectivity in a Shank3 complete knockout model of autism

Altered mGluR5-Homer scaffolds and corticostriatal connectivity in a Shank3 complete knockout model of autism

Human neuroimaging studies suggest that aberrant neural connectivity underlies behavioural deficits in autism spectrum disorders (ASDs), but the molecular and neural circuit mechanisms underlying ASDs remain elusive. Here, we describe a complete knockout mouse model of the autism-associated Shank3 g...

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Bibliographic Details
Main Authors: Wang, Xiaoming, Bey, Alexandra L., Katz, Brittany M., Badea, Alexandra, Kim, Namsoo, David, Lisa K., Duffney, Lara J., Kumar, Sunil, Mague, Stephen D., Hulbert, Samuel W., Dutta, Nisha, Hayrapetyan, Volodya, Yu, Chunxiu, Gaidis, Erin, Zhao, Shengli, Ding, Jin-Dong, Xu, Qiong, Chung, Leeyup, Rodriguiz, Ramona M., Wang, Fan, Weinberg, Richard J., Wetsel, William C., Dzirasa, Kafui, Yin, Henry, Jiang, Yong-hui
Format: Online
Language:English
Published: Nature Publishing Group 2016
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4866051/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4866051/

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