A human genome-wide loss-of-function screen identifies effective chikungunya antiviral drugs

A human genome-wide loss-of-function screen identifies effective chikungunya antiviral drugs

Chikungunya virus (CHIKV) is a globally spreading alphavirus against which there is no commercially available vaccine or therapy. Here we use a genome-wide siRNA screen to identify 156 proviral and 41 antiviral host factors affecting CHIKV replication. We analyse the cellular pathways in which human...

Full description

Bibliographic Details
Main Authors: Karlas, Alexander, Berre, Stefano, Couderc, Thérèse, Varjak, Margus, Braun, Peter, Meyer, Michael, Gangneux, Nicolas, Karo-Astover, Liis, Weege, Friderike, Raftery, Martin, Schönrich, Günther, Klemm, Uwe, Wurzlbauer, Anne, Bracher, Franz, Merits, Andres, Meyer, Thomas F., Lecuit, Marc
Format: Online
Language:English
Published: Nature Publishing Group 2016
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4865845/

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4865845/

Similar Items