Ultra-protective ventilation and hypoxemia
Partial extracorporeal CO2 removal allows a decreasing tidal volume without respiratory acidosis in patients with acute respiratory distress syndrome. This, however, may be associated with worsening hypoxemia, due to several mechanisms, such as gravitational and reabsorption atelectasis, due to a de...
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| Format: | Online |
| Language: | English |
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BioMed Central
2016
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4865006/ |
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pubmed-48650062016-05-13 Ultra-protective ventilation and hypoxemia Gattinoni, Luciano Commentary Partial extracorporeal CO2 removal allows a decreasing tidal volume without respiratory acidosis in patients with acute respiratory distress syndrome. This, however, may be associated with worsening hypoxemia, due to several mechanisms, such as gravitational and reabsorption atelectasis, due to a decrease in mean airway pressure and a critically low ventilation-perfusion ratio, respectively. In addition, an imbalance between alveolar and artificial lung partial pressures of nitrogen may accelerate the process. Finally, the decrease in the respiratory quotient, leading to unrecognized alveolar hypoxia and monotonous low plateau pressures preventing critical opening, may contribute to hypoxemia. BioMed Central 2016-05-12 2016 /pmc/articles/PMC4865006/ /pubmed/27170273 http://dx.doi.org/10.1186/s13054-016-1310-9 Text en © Gattinoni. 2016 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
| repository_type |
Open Access Journal |
| institution_category |
Foreign Institution |
| institution |
US National Center for Biotechnology Information |
| building |
NCBI PubMed |
| collection |
Online Access |
| language |
English |
| format |
Online |
| author |
Gattinoni, Luciano |
| spellingShingle |
Gattinoni, Luciano Ultra-protective ventilation and hypoxemia |
| author_facet |
Gattinoni, Luciano |
| author_sort |
Gattinoni, Luciano |
| title |
Ultra-protective ventilation and hypoxemia |
| title_short |
Ultra-protective ventilation and hypoxemia |
| title_full |
Ultra-protective ventilation and hypoxemia |
| title_fullStr |
Ultra-protective ventilation and hypoxemia |
| title_full_unstemmed |
Ultra-protective ventilation and hypoxemia |
| title_sort |
ultra-protective ventilation and hypoxemia |
| description |
Partial extracorporeal CO2 removal allows a decreasing tidal volume without respiratory acidosis in patients with acute respiratory distress syndrome. This, however, may be associated with worsening hypoxemia, due to several mechanisms, such as gravitational and reabsorption atelectasis, due to a decrease in mean airway pressure and a critically low ventilation-perfusion ratio, respectively. In addition, an imbalance between alveolar and artificial lung partial pressures of nitrogen may accelerate the process. Finally, the decrease in the respiratory quotient, leading to unrecognized alveolar hypoxia and monotonous low plateau pressures preventing critical opening, may contribute to hypoxemia. |
| publisher |
BioMed Central |
| publishDate |
2016 |
| url |
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4865006/ |
| _version_ |
1613578572573704192 |