Targeted next‐generation sequencing of 22 mismatch repair genes identifies Lynch syndrome families

Targeted next‐generation sequencing of 22 mismatch repair genes identifies Lynch syndrome families

Causative germline mutations in mismatch repair (MMR) genes can only be identified in ~50% of families with a clinical diagnosis of the inherited colorectal cancer (CRC) syndrome hereditary nonpolyposis colorectal cancer (HNPCC)/Lynch syndrome (LS). Identification of these patients are critical as t...

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Bibliographic Details
Main Authors: Talseth‐Palmer, Bente A., Bauer, Denis C., Sjursen, Wenche, Evans, Tiffany J., McPhillips, Mary, Proietto, Anthony, Otton, Geoffrey, Spigelman, Allan D., Scott, Rodney J.
Format: Online
Language:English
Published: John Wiley and Sons Inc. 2016
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4864822/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4864822/

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