Acinetobacter baumannii Genes Required for Bacterial Survival during Bloodstream Infection

A. baumannii is a significant cause of bacterial bloodstream infection in humans. Since multiple antibiotic resistance is becoming more common among strains of A. baumannii, there is an urgent need to develop novel tools to treat infections caused by this dangerous pathogen. To develop knowledge-gui...

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Main Authors:	Subashchandrabose, Sargurunathan, Smith, Sara, DeOrnellas, Valerie, Crepin, Sebastien, Kole, Monica, Zahdeh, Carina, Mobley, Harry L. T.
Format:	Online
Language:	English
Published:	American Society for Microbiology 2015
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4863628/

id	pubmed-4863628
recordtype	oai_dc
spelling	pubmed-48636282016-06-14 Acinetobacter baumannii Genes Required for Bacterial Survival during Bloodstream Infection Subashchandrabose, Sargurunathan Smith, Sara DeOrnellas, Valerie Crepin, Sebastien Kole, Monica Zahdeh, Carina Mobley, Harry L. T. Research Article A. baumannii is a significant cause of bacterial bloodstream infection in humans. Since multiple antibiotic resistance is becoming more common among strains of A. baumannii, there is an urgent need to develop novel tools to treat infections caused by this dangerous pathogen. To develop knowledge-guided treatment approaches for A. baumannii, a thorough understanding of the mechanism by which this pathogen causes bloodstream infection is required. Here, using a mouse model of infection, we report the identification of A. baumannii genes that are critical for the ability of this pathogen to cause bloodstream infections. This study lays the foundation for future research on A. baumannii genes that can be targeted to develop novel therapeutics against this emerging human pathogen. American Society for Microbiology 2015-11-04 /pmc/articles/PMC4863628/ /pubmed/27303682 http://dx.doi.org/10.1128/mSphere.00013-15 Text en Copyright © 2015 Subashchandrabose et al. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license (http://creativecommons.org/licenses/by/4.0/) .
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Subashchandrabose, Sargurunathan Smith, Sara DeOrnellas, Valerie Crepin, Sebastien Kole, Monica Zahdeh, Carina Mobley, Harry L. T.
spellingShingle	Subashchandrabose, Sargurunathan Smith, Sara DeOrnellas, Valerie Crepin, Sebastien Kole, Monica Zahdeh, Carina Mobley, Harry L. T. Acinetobacter baumannii Genes Required for Bacterial Survival during Bloodstream Infection
author_facet	Subashchandrabose, Sargurunathan Smith, Sara DeOrnellas, Valerie Crepin, Sebastien Kole, Monica Zahdeh, Carina Mobley, Harry L. T.
author_sort	Subashchandrabose, Sargurunathan
title	Acinetobacter baumannii Genes Required for Bacterial Survival during Bloodstream Infection
title_short	Acinetobacter baumannii Genes Required for Bacterial Survival during Bloodstream Infection
title_full	Acinetobacter baumannii Genes Required for Bacterial Survival during Bloodstream Infection
title_fullStr	Acinetobacter baumannii Genes Required for Bacterial Survival during Bloodstream Infection
title_full_unstemmed	Acinetobacter baumannii Genes Required for Bacterial Survival during Bloodstream Infection
title_sort	acinetobacter baumannii genes required for bacterial survival during bloodstream infection
description	A. baumannii is a significant cause of bacterial bloodstream infection in humans. Since multiple antibiotic resistance is becoming more common among strains of A. baumannii, there is an urgent need to develop novel tools to treat infections caused by this dangerous pathogen. To develop knowledge-guided treatment approaches for A. baumannii, a thorough understanding of the mechanism by which this pathogen causes bloodstream infection is required. Here, using a mouse model of infection, we report the identification of A. baumannii genes that are critical for the ability of this pathogen to cause bloodstream infections. This study lays the foundation for future research on A. baumannii genes that can be targeted to develop novel therapeutics against this emerging human pathogen.
publisher	American Society for Microbiology
publishDate	2015
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4863628/
_version_	1613578041348325376

Acinetobacter baumannii Genes Required for Bacterial Survival during Bloodstream Infection

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